Review the side-effects of Benznidazole as documented in medical literature. The term "side effects" refers to unintended effects that can occur as a result of taking the medication. In majority of the instances these side-effects are mild and easily tolerable, however sometimes they can be more severe and can be detrimental.
If the side effects are not tolerable adjusting the dosage or switching to a different medication can help to manage or overcome side effects. If you have any doubts or questions, we recommend seeking advice from your doctor or pharmacist.
Common: Weight loss, rash, pain in the abdomen, headache
Gastrointestinal: Loss of appetite, diarrhea, vomiting, nausea, pain in the abdomen, dry mouth
Central nervous system: Peripheral neuropathy, paresthesia, dizziness, headache, confusion, inability to concentrate, tremor. The treatment should be stopped if neurological symptoms appear.
Blood: Reduced blood counts of red blood cells, white blood cells and platelets, eosinophilia
Skin: Rashes, eczema, allergic or exfoliative dermatitis, itching, toxic epidermal necrolysis, erythema multiforme, peeling of skin. The treatment should be discontinued if the skin reactions are associated with lymph node enlargement, fever and/or purpura (small purple spots due to small bleeds under the skin).
Others: Edema, fever, muscle pain, hepatitis, fatigue, asthenia, allergic reaction, increased levels of alkaline phosphatase and bilirubin, joint pain
• Tablets of benznidazole should be taken at least after 3 days of stopping alcohol consumption to avoid disulfiram-like reactions such as nausea, headache, abdominal cramps, and flushing.
• Benznidazole 100 mg tablets are scored so that they are easy to break into either half or quarter as advised by the physician.
If the side effects are not tolerable adjusting the dosage or switching to a different medication can help to manage or overcome side effects. If you have any doubts or questions, we recommend seeking advice from your doctor or pharmacist.
Common: Weight loss, rash, pain in the abdomen, headache
Gastrointestinal: Loss of appetite, diarrhea, vomiting, nausea, pain in the abdomen, dry mouth
Central nervous system: Peripheral neuropathy, paresthesia, dizziness, headache, confusion, inability to concentrate, tremor. The treatment should be stopped if neurological symptoms appear.
Blood: Reduced blood counts of red blood cells, white blood cells and platelets, eosinophilia
Skin: Rashes, eczema, allergic or exfoliative dermatitis, itching, toxic epidermal necrolysis, erythema multiforme, peeling of skin. The treatment should be discontinued if the skin reactions are associated with lymph node enlargement, fever and/or purpura (small purple spots due to small bleeds under the skin).
Others: Edema, fever, muscle pain, hepatitis, fatigue, asthenia, allergic reaction, increased levels of alkaline phosphatase and bilirubin, joint pain
Other Precautions :
• Adverse reactions should be reported to the emergency center as early as possible.• Tablets of benznidazole should be taken at least after 3 days of stopping alcohol consumption to avoid disulfiram-like reactions such as nausea, headache, abdominal cramps, and flushing.
• Benznidazole 100 mg tablets are scored so that they are easy to break into either half or quarter as advised by the physician.
