Drugs for Peptic Ulcer

Aluminum Hydroxide and Magnesium Hydroxide contains antacids, prescribed for preventing ulcers, heartburn relief, acid indigestion and stomach upsets. Aluminum Hydroxide and Magnesium Hydroxide neutralizes acid in the stomach.

Famotidine is a histamine (H2-receptor antagonist), prescribed for ulcer.

Glycopyrrolate is a muscarinic anticholinergic agent, prescribed for peptic ulcer in combination with other medicines and also used in anesthesia as preoperative medication. It reduces acid and saliva secretions.

Isopropamide is used for the treatment of peptic ulcer. It is also used for the treatment of other gastrointestinal disorders like nervous dyspepsia and irritable bowel syndrome along with trifluoperazine.

Lafutidine is an antacid, prescribed for ulcer.

Mepenzolate is an antimuscarinic agent, prescribed for the treatment of peptic ulcer combined with other medication. It decreases acid secretion in the stomach and control intestinal spasms.

Misoprostol is a synthetic prostaglandin; prescribed for ulcer, labor induction, induced abortion, miscarriage, postpartum hemorrhage (blood loss during birth) and other gynecological uses.

Omeprazole and Domperidone contains a proton pump inhibitor and antidopaminergic agent, prescribed for ulcers, indigestion and acid stomach.

Oxyphenonium is an antimuscarinic agent, prescribed for peptic ulcer and it prevents muscle spasm in the gastrointestinal tract.

Pantoprazole is a proton-pump inhibitor, prescribed for gastroesophageal reflux disease (GERD), ulcers, Zollinger-Ellison Syndrome, and erosive esophagitis. It decreases the amount of acid made in the stomach.

Pirenzepine is an antacid, prescribed for peptic ulcer.

Propantheline is an antimuscarinic agent, prescribed for peptic ulcer, and urinary incontinence.

Ranitidine is an antacid, antireflux agent and antiulcerant, prescribed for peptic ulcer.

Rebamipide is prescribed for the treatment of peptic ulcers, gastroduodenal ulcers, and gastric disorders. It is indicated during bleeding, erosion, redness, and edema (all signs of gastric mucosal lesions) that occur in acute gastritis and acute exacerbation of chronic gastritis. Rebamipide is an amino acid derivative that works by enhancing the mucosal defense system and scavenging free radicals in the body. Rebamipide is also an effective and safe drug in the treatment of recurrent oral ulcers in Behcet’s disease.

Revaprazan is prescribed for the treatment of duodenal ulcer, gastric ulcer and gastritis. Revaprazan is classified a reversible acid pump antagonist (APA or a potassium-competitive acid blocker) since it acts in a mechanism different from irreversible proton pump inhibitors, such as omeprazole. Revaprazan is not dependent upon secretion status of a proton pump or acid activation of a drug in a stomach. Revaprazan has long-lasting acid-suppressive effects. Revaprazan is approved for use only in Korea and India. 

Troxipide is used for the treatment of peptic ulcers, gastroesophageal reflex disease, to manage gastric mucosal lesions (erosion, hemorrhage, redness and edema) in acute gastritis and acute exacerbation of chronic gastritis. Troxipide is a novel gastroprotective agent with anti-ulcer, anti-inflammatory and mucus secreting properties; its action does not depend on the pH of stomach or duodenum.