Trifluridine and tipiracil combination is available in a tablet form which should be taken by mouth twice daily.
The tablets of trifluridine and tipiracil should be swallowed with a sufficient quantity of water within 1 hour after taking the morning and evening meals.
Take the tablets of trifluridine and tipiracil around the same time every day.
Trifluridine and tipiracil combination is a cytotoxic agent which affects healthy cells. So, patients must be advised to wash with clean water thoroughly if the tablet contents comes into contact with the skin or eyes.
The recommended initial dose of trifluridine and tipiracil is 35 mg/m2 given from days 1 to 5 and from days 8 to 12 of each 28-day treatment cycle.
The maximum dose should not exceed 80 mg per dose. The treatment with trifluridine and tipiracil combination can be taken as long as the patient benefits from it or until the treatment with the drug does not result in intolerable toxicity.
Dose adjustments can be considered if any side effects occur. A maximum of up to 3 dose reductions can be considered and the dose once reduced should not be increased.
The minimum dose of trifluridine and tipiracil is 20 mg/m2.
• If there is an allergy to trifluridine and tipiracil
• Pregnancy and breastfeeding
• Children (due to lack of safety and effectiveness data)
• Severe or end-stage kidney disease
• Liver damage
Never take another dose of trifluridine and tipiracil tablets to make up for the missed dose which can be harmful.
The tablets of trifluridine and tipiracil should be swallowed with a sufficient quantity of water within 1 hour after taking the morning and evening meals.
Take the tablets of trifluridine and tipiracil around the same time every day.
Trifluridine and tipiracil combination is a cytotoxic agent which affects healthy cells. So, patients must be advised to wash with clean water thoroughly if the tablet contents comes into contact with the skin or eyes.
Dosage & When it is to be taken
The dose of trifluridine and tipiracil combination is calculated based on the body surface area of the individual patient.The recommended initial dose of trifluridine and tipiracil is 35 mg/m2 given from days 1 to 5 and from days 8 to 12 of each 28-day treatment cycle.
The maximum dose should not exceed 80 mg per dose. The treatment with trifluridine and tipiracil combination can be taken as long as the patient benefits from it or until the treatment with the drug does not result in intolerable toxicity.
Dose adjustments can be considered if any side effects occur. A maximum of up to 3 dose reductions can be considered and the dose once reduced should not be increased.
The minimum dose of trifluridine and tipiracil is 20 mg/m2.
When it is not to be taken (Contraindications)
Trifluridine and tipiracil should not be used in patients-• If there is an allergy to trifluridine and tipiracil
• Pregnancy and breastfeeding
• Children (due to lack of safety and effectiveness data)
• Severe or end-stage kidney disease
• Liver damage
What if you Miss a Dose of Trifluridine and Tipiracil?
If a dose of trifluridine and tipiracil is missed do not take the missed dose but continue with the next dose.Never take another dose of trifluridine and tipiracil tablets to make up for the missed dose which can be harmful.
