Ribociclib comes in a tablet form and should be taken by mouth either with or without food.
The tablets should not be chewed or crushed but to be swallowed as a whole with sufficient quantity of water.
If vomiting occurs after taking the medicine, do not take another dose immediately. The next dose should be taken only on the following day.
• The recommended adult dose of ribociclib tablets is 600mg (3 tablets of 200 mg each) taken orally once a day in the morning for the first 21 days followed by 7 days off in a 28-day treatment cycle.
• In addition, the patient is also administered the aromatase inhibitor letrozole 2.5mg once daily throughout the 28-day cycle.
Dosage modification when adverse reactions are reported:
• The first dose reduction is 400mg/day (2 tablets of 200mg) which can be reduced to further 200mg/day (1 tablet of 200mg) in case the adverse reactions are prolonged.
• Drug treatment should be discontinued if adverse reactions occur even at the dose of 200mg once daily.
• Allergy or hypersensitivity to ribociclib Pregnant women (as it causes harm to the fetus or may result in birth defects). Pregnancy should be avoided for at least three weeks after stopping the treatment. Currently, the drug is approved for use only in postmenopausal women.
• Breastfeeding women
• Uncontrolled or significant heart disease such as heart attack, unstable angina, congestive heart failure and abnormally slow heart rhythms
• Electrolyte abnormalities
The tablets should not be chewed or crushed but to be swallowed as a whole with sufficient quantity of water.
If vomiting occurs after taking the medicine, do not take another dose immediately. The next dose should be taken only on the following day.
Dosage & When it is to be taken
Breast cancer:• The recommended adult dose of ribociclib tablets is 600mg (3 tablets of 200 mg each) taken orally once a day in the morning for the first 21 days followed by 7 days off in a 28-day treatment cycle.
• In addition, the patient is also administered the aromatase inhibitor letrozole 2.5mg once daily throughout the 28-day cycle.
Dosage modification when adverse reactions are reported:
• The first dose reduction is 400mg/day (2 tablets of 200mg) which can be reduced to further 200mg/day (1 tablet of 200mg) in case the adverse reactions are prolonged.
• Drug treatment should be discontinued if adverse reactions occur even at the dose of 200mg once daily.
When it is not to be taken (Contraindications)
Ribociclib is not recommended in the following conditions:• Allergy or hypersensitivity to ribociclib Pregnant women (as it causes harm to the fetus or may result in birth defects). Pregnancy should be avoided for at least three weeks after stopping the treatment. Currently, the drug is approved for use only in postmenopausal women.
• Breastfeeding women
• Uncontrolled or significant heart disease such as heart attack, unstable angina, congestive heart failure and abnormally slow heart rhythms
• Electrolyte abnormalities
