• Prothionamide should be taken orally.
• Adults and children can take it as one dose to maximize peak levels (particularly for daily doses less than 750 mg) if they can tolerate it.
• The dose can be split into two if once a day dose is not tolerated.
• Dose may have to be gradually escalated for adults. Increase dose by 250 mg every 3 to 5 days.
• Take with or after meals to reduce gastrointestinal adverse effects.
Adults: 15-20 mg/kg/day that amounts to around 500-750 mg per day; maximum dose per day should not exceed 1000 mg or 1 gram
Children: 15-20 mg/kg/day with a maximum daily dose of 1000 mg
• Prothionamide is also contraindicated in pregnant and lactating women and in patients who have severe renal disease and porphyria.
• Adults and children can take it as one dose to maximize peak levels (particularly for daily doses less than 750 mg) if they can tolerate it.
• The dose can be split into two if once a day dose is not tolerated.
• Dose may have to be gradually escalated for adults. Increase dose by 250 mg every 3 to 5 days.
• Take with or after meals to reduce gastrointestinal adverse effects.
Dosage & When it is to be taken
The recommended dose for prothionamide isAdults: 15-20 mg/kg/day that amounts to around 500-750 mg per day; maximum dose per day should not exceed 1000 mg or 1 gram
Children: 15-20 mg/kg/day with a maximum daily dose of 1000 mg
When it is not to be taken (Contraindications)
• Prothionamide is contraindicated in patients with known allergy to the drug.• Prothionamide is also contraindicated in pregnant and lactating women and in patients who have severe renal disease and porphyria.
