Dosage & When it is to be taken

Adult: PO- Opioid dependence- Initial: 25 mg, then up to 50 mg/day if no withdrawal signs. Maintenance: 350 mg/week given as 50 mg/day or divided in 3 doses (given on 3 days of the week) for improved compliance.
Adjunct in alcohol dependence- 50 mg/day.
IM- Adjunct in alcohol dependence- 380 mg 4 weekly.

When it is not to be taken (Contraindications)

Contraindicated in patients who are concurrently dependent on opioids, acute liver inflammation or liver failure, acute opioid withdrawal and patients on therapeutic opioid analgesics.