• Naldemedine comes as a tablet to be taken by mouth and can be taken either with or without food.
• The naldemedine tablets should be taken at the same time each day and exactly as prescribed by the doctor.
• Alteration of opioid dosing regimen is not required before starting the treatment with naldemedine.
• Patients who are allergic to naldemedine
• Known or suspected gastrointestinal obstruction
• Stomach or intestinal disorders such as diverticulitis, Crohn's disease or stomach or colorectal cancer due to a risk of perforation
• Severe hepatic impairment. No dose modification is needed in mild-to-moderate liver impairment
• Children less than 18 years of age
• Pregnancy due to the possibility of opioid withdrawal symptom in the newborn
• Breastfeeding should be started only after 3 days of the last dose of naldemedine tablets.
• The naldemedine tablets should be taken at the same time each day and exactly as prescribed by the doctor.
• Alteration of opioid dosing regimen is not required before starting the treatment with naldemedine.
Dosage & When it is to be taken
• The recommended adult dose of naldemedine is 0.2 mg once a day.When it is not to be taken (Contraindications)
Naldemedine is not recommended in the following conditions:• Patients who are allergic to naldemedine
• Known or suspected gastrointestinal obstruction
• Stomach or intestinal disorders such as diverticulitis, Crohn's disease or stomach or colorectal cancer due to a risk of perforation
• Severe hepatic impairment. No dose modification is needed in mild-to-moderate liver impairment
• Children less than 18 years of age
• Pregnancy due to the possibility of opioid withdrawal symptom in the newborn
• Breastfeeding should be started only after 3 days of the last dose of naldemedine tablets.
