• Midostaurin comes in a capsule form to be taken by mouth along with food. It should be taken at the same time each day.
• The capsules should be swallowed as a whole with sufficient quantity of water.
• Do not crush or open the capsule.
• If vomiting occurs after taking midostaurin, do not take another dose and continue with the next scheduled dose.
• The prescribed adult dose is 50 mg orally taken twice daily on day 8 to 21 of each cycle of induction with daunorubicin and cytarabine, and days 8 to 21 days of each cycle of consolidation with a high dose of cytarabine in patients who show FLT3 mutation positivity detected by an FDA approved test.
Treatment of ASM, SM-AHN, MCL:
• The recommended adult dose is 100 mg orally taken twice daily and the treatment should be continued until the disease progression or occurrence of toxicity.
• Allergy or known hypersensitivity to midostaurin
• Lung-related toxicity with the drug
• Pregnancy and breastfeeding
• The capsules should be swallowed as a whole with sufficient quantity of water.
• Do not crush or open the capsule.
• If vomiting occurs after taking midostaurin, do not take another dose and continue with the next scheduled dose.
Dosage & When it is to be taken
Acute myeloid leukemia:• The prescribed adult dose is 50 mg orally taken twice daily on day 8 to 21 of each cycle of induction with daunorubicin and cytarabine, and days 8 to 21 days of each cycle of consolidation with a high dose of cytarabine in patients who show FLT3 mutation positivity detected by an FDA approved test.
Treatment of ASM, SM-AHN, MCL:
• The recommended adult dose is 100 mg orally taken twice daily and the treatment should be continued until the disease progression or occurrence of toxicity.
When it is not to be taken (Contraindications)
Midostaurin should not be used in patients with:• Allergy or known hypersensitivity to midostaurin
• Lung-related toxicity with the drug
• Pregnancy and breastfeeding
