It comes as a tablet to take by mouth, with or without food.It also comes as a solution for injection to be administered by a healthcare provide into a large muscle.
Oral & IMChoriocarcinoma(Ectopic Pregnancy)- 15-30 mg/day for 5 days, repeat after an interval of at least 1 week for 3-5 courses.
Mycosis fungoides- 2.5-10 mg/day to induce remission.
Rheumatoid arthritis- 7.5 mg once weekly, adjust if needed. Up to 20 mg/wk.
Crohn's disease- 12.5-22.5 mg once weekly for up to 1 year.
PO/IV/IM- Psoriasis- 10-25 mg once wkly, adjust subsequent doses if needed.
IV- Osteosarcoma- 12-15 g/m2 as infusion, followed by folinic acid.
Breast cancer 10-60 mg/m2 often with cyclophosphamide and fluorouracil. Advanced lymphosarcoma Up to 30 mg/kg, followed by folinic acid rescue. Acute lymphoblastic leukaemia Maintenance: 2.5 mg/kg every 14 days.
Dosage & When it is to be taken
Oral Burkitt's lymphoma- 10-25 mg/day for 4-8 days, repeat after 7-10 days.Oral & IMChoriocarcinoma(Ectopic Pregnancy)- 15-30 mg/day for 5 days, repeat after an interval of at least 1 week for 3-5 courses.
Mycosis fungoides- 2.5-10 mg/day to induce remission.
Rheumatoid arthritis- 7.5 mg once weekly, adjust if needed. Up to 20 mg/wk.
Crohn's disease- 12.5-22.5 mg once weekly for up to 1 year.
PO/IV/IM- Psoriasis- 10-25 mg once wkly, adjust subsequent doses if needed.
IV- Osteosarcoma- 12-15 g/m2 as infusion, followed by folinic acid.
Breast cancer 10-60 mg/m2 often with cyclophosphamide and fluorouracil. Advanced lymphosarcoma Up to 30 mg/kg, followed by folinic acid rescue. Acute lymphoblastic leukaemia Maintenance: 2.5 mg/kg every 14 days.
When it is not to be taken (Contraindications)
It should not be administered during breast feeding. It should also not be used in patients allergic to the drug, pregnancy, liver disease, in alcoholics, people with low blood counts or decreased immunity.Drug Name : Methotrexate
This medication is an antimetabolite, curative in choriocarcinoma (cancer of the tissue that normally would develop into placenta).Trade Names/Brand Names of Methotrexate
India :
Onotrex |
Vibzi (7.5mg) |
Carditrex |
Nidtrex |
Dermotrex (5mg) |
Trex |
Darmatrex (5mg) |
Dermotrex (7.5mg) |
Nidtrex |
Carditrex