• Meropenem and vaborbactam injection is available as a powder for reconstitution which has to be mixed with 0.9% sodium chloride injection.
• Mix the contents of the vial gently and dilute further with 0.9% sodium chloride injection to achieve meropenem and vaborbactam concentration of 0.05 g/ml each; this should be transferred into an intravenous bag for infusion.
• The infusion must be administered directly into the vein over a period of 3 hours.
• The infusion should be inspected for the presence of particulate matter or discoloration before administering and should be discarded if present.
• The duration of treating with meropenem and vaborbactam is for up to 14 days.
• Dose adjustment is required in patients with kidney disorder based on the estimated glomerular filtration rate (GFR).
Estimated GFR at least 50 ml/min/1.73m2 - no dose adjustment needed
Estimated GFR 30 to 49 ml/min/1.73m2 - 2 g three times daily
Estimated GFR 15 to 29 ml/min/1.73m2 - 2 g twice daily
Estimated GFR less than 15 ml/min/1.73m2 - 1 g twice daily
• Hypersensitivity to meropenem and vaborbactam or any other β-lactams
• Viral Infections such as common cold or flu
• History of seizures
• Children below 18 years of age
• Mix the contents of the vial gently and dilute further with 0.9% sodium chloride injection to achieve meropenem and vaborbactam concentration of 0.05 g/ml each; this should be transferred into an intravenous bag for infusion.
• The infusion must be administered directly into the vein over a period of 3 hours.
• The infusion should be inspected for the presence of particulate matter or discoloration before administering and should be discarded if present.
Dosage & When it is to be taken
• The recommended dose of this fixed dose combination is 4 grams (containing 2 g of meropenem and 2 g of vaborbactam) which is administered three times daily by intravenous infusion.• The duration of treating with meropenem and vaborbactam is for up to 14 days.
• Dose adjustment is required in patients with kidney disorder based on the estimated glomerular filtration rate (GFR).
Estimated GFR at least 50 ml/min/1.73m2 - no dose adjustment needed
Estimated GFR 30 to 49 ml/min/1.73m2 - 2 g three times daily
Estimated GFR 15 to 29 ml/min/1.73m2 - 2 g twice daily
Estimated GFR less than 15 ml/min/1.73m2 - 1 g twice daily
When it is not to be taken (Contraindications)
Meropenem and vaborbactam combination should not be used in patients with-• Hypersensitivity to meropenem and vaborbactam or any other β-lactams
• Viral Infections such as common cold or flu
• History of seizures
• Children below 18 years of age
