• The fixed emetogenic combination of fosnetupitant and palonosetron is available as an injection for administering directly into the vein by a healthcare provider.
• The vial should be reconstituted aseptically with 20 ml of 5% dextrose or 0.9% sodium chloride introduced into an infusion bag containing 30 ml of 5% dextrose or 0.9% sodium chloride to make up a volume of 50 ml solution.
• The reconstitution procedures should be done gently to avoid foaming.
• The final diluted solution should be administered slowly for at least 30 minutes into the vein starting 30 minutes before chemotherapy.
• The IV line should be flushed with the same solution used for reconstitution at the end of the infusion to ensure complete drug administration.
• The total time right from reconstitution to the start of infusion should not be more than 3 hours.
• The vial should be reconstituted with 5% dextrose or 0.9% sodium chloride injection and must be administered 30 minutes before starting chemotherapy.
• Dexamethasone 12 mg should also be taken 30 minutes before initiating chemotherapy.
• Allergic to Fosnetupitant and Palonosetron
• Taking anthracycline chemotherapy (e.g., Daunorubicin, Doxorubicin, Epirubicin)
• Taking cyclophosphamide chemotherapy
• Below 18 years old
• The vial should be reconstituted aseptically with 20 ml of 5% dextrose or 0.9% sodium chloride introduced into an infusion bag containing 30 ml of 5% dextrose or 0.9% sodium chloride to make up a volume of 50 ml solution.
• The reconstitution procedures should be done gently to avoid foaming.
• The final diluted solution should be administered slowly for at least 30 minutes into the vein starting 30 minutes before chemotherapy.
• The IV line should be flushed with the same solution used for reconstitution at the end of the infusion to ensure complete drug administration.
• The total time right from reconstitution to the start of infusion should not be more than 3 hours.
Dosage & When it is to be taken
• The recommended dose of fosnetupitant and palonosetron injection is a single vial containing 235 mg of fosnetupitant and 0.25 mg of palonosetron administered as a reconstituted solution.• The vial should be reconstituted with 5% dextrose or 0.9% sodium chloride injection and must be administered 30 minutes before starting chemotherapy.
• Dexamethasone 12 mg should also be taken 30 minutes before initiating chemotherapy.
When it is not to be taken (Contraindications)
Fosnetupitant and Palonosetron should not be used in patients-• Allergic to Fosnetupitant and Palonosetron
• Taking anthracycline chemotherapy (e.g., Daunorubicin, Doxorubicin, Epirubicin)
• Taking cyclophosphamide chemotherapy
• Below 18 years old
