It comes as a capsule to take by mouth, at bedtime. It is also available as an injection, to be administered by a physician.
Alcohol withdrawal syndrome- Per capsule contains clomethiazole base 192 mg: 9-12 cap/day in divided doses on 1st day, reduce dose gradually over the next 5 days. Not to be used for >9 days.
Sedation- 1 capsule (192 mg of base) 3 times/day.
IV- Status epilepticus as 0.8% solution: Initial: 5-15 ml/min, up to 40-100 ml. Usual maintenance: 0.5-1 ml/min. Alcohol withdrawal syndrome as 0.8% solution: Initial: 3-7.5 ml/min until shallow sleep is induced, then reduce to 0.5-1 ml/min to maintain sleep and spontaneous breathing.
Pre-eclamptic toxaemia as 0.8% solution: Initial: 0.5-0.75 ml/min during labor. Maintain at 0.5 ml/min for 12 hour post-delivery.
Heminevrin capsule
Dosage & When it is to be taken
Oral- Insomnia- 1 or 2 capsule (192 or 384 mg of the base or the equiv)/day at bedtime.Alcohol withdrawal syndrome- Per capsule contains clomethiazole base 192 mg: 9-12 cap/day in divided doses on 1st day, reduce dose gradually over the next 5 days. Not to be used for >9 days.
Sedation- 1 capsule (192 mg of base) 3 times/day.
IV- Status epilepticus as 0.8% solution: Initial: 5-15 ml/min, up to 40-100 ml. Usual maintenance: 0.5-1 ml/min. Alcohol withdrawal syndrome as 0.8% solution: Initial: 3-7.5 ml/min until shallow sleep is induced, then reduce to 0.5-1 ml/min to maintain sleep and spontaneous breathing.
Pre-eclamptic toxaemia as 0.8% solution: Initial: 0.5-0.75 ml/min during labor. Maintain at 0.5 ml/min for 12 hour post-delivery.
When it is not to be taken (Contraindications)
Acute lung insufficiency.Drug Name : Clomethiazole
This medication is a hypnotic and sedative, prescribed for treating and preventing symptoms of acute alcohol withdrawal, sleeplessness, restlessness, and agitation (excitement).Trade Names/Brand Names of Clomethiazole
International :
Heminevrin capsule
