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How to Take Cerliponase Alfa and it's Dose


• Cerliponase alfa comes in a concentration of 150mg/5ml in two single dose vials along with intraventricular electrolyte injection of 5ml in a single dose vial.
• It is administered into the cerebral ventricle (central cavity of the brain) through a surgically implanted reservoir connected to the catheter of an intraventricular access device.
• The whole process should be done under aseptic technique and the first dose of infusion should be carried out at least 5 to 7 days after implantation of the device.
• Since allergic reactions can take place, the patients should be pretreated with antihistamines with or without antipyretics or corticosteroids 30-60 minutes before starting the infusion.

Dosage & When it is to be taken

• The recommended dosage of cerliponase alfa for patients 3 years of age and older is 300mg administered using intraventricular infusion every other week.

• The drug infusion should be followed by intraventricular electrolytes at a rate of 2.5ml per hour. The total time of infusion for both should be approximately 4 and a half hours.

When it is not to be taken (Contraindications)

Cerliponase alfa is contraindicated on the following conditions:

a) Allergy to the drug

b) The presence of intraventricular access device related complications which include:
• Failure of the device
• Leakage
• Signs of device-related infection such as swelling, scalp redness, extravasation of fluid, bulging of scalp around or above intraventricular access device.

c) Patients with ventriculoperitoneal shunts (catheter that connects the brain to the abdomen to reduce the fluid content in the brain) due to the risk of the following:
• Bleeding or blood clot in brain
• Cerebrospinal fluid leakage under the skin in the shunt area
• Brain swelling and damage
• Infection occurring in the shunt, brain or abdomen
• Seizures

Drug Name : Cerliponase Alfa

Cerliponase alfa is recombinant human tripeptidyl peptidase-1 enzyme (TPP1) which is required for normal brain development.


Trade Names/Brand Names of Cerliponase Alfa

India :


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