• Benznidazole comes in a tablet form to be taken by mouth along with food. The tablets can be swallowed with a sufficient quantity of water.
• If children find the tablets difficult to swallow, the drug can be prepared in a slurry form by mixing with a necessary amount of water and should be taken immediately. The dosage cup can be rinsed with an additional 80 ml of water which should be drunk. The rinsing and drinking should be repeated twice.
• Symptoms of Chagas disease may show improvement even before the complete infection subsides. However, the benznidazole tablets should not be stopped suddenly and the duration of the treatment should be completed as prescribed.
• Do not take smaller or larger amounts of benznidazole tablets but take exactly as prescribed by the physician.
• The prescribed dose is 5 mg/kg to 8 mg/kg taken orally in two divided doses (every 12 hourly) for a period of 60 days.
• Allergy to benznidazole
• Pregnancy and breastfeeding as it cause teratogenicity
• Kidney or liver disease since it has not been evaluated in these patients
• Consumption of alcohol or products containing propylene glycol. Alcohol should be avoided for at least three days after completion of benznidazole treatment
• Disulfiram therapy taken within two weeks before starting benznidaloze treatment
• If children find the tablets difficult to swallow, the drug can be prepared in a slurry form by mixing with a necessary amount of water and should be taken immediately. The dosage cup can be rinsed with an additional 80 ml of water which should be drunk. The rinsing and drinking should be repeated twice.
• Symptoms of Chagas disease may show improvement even before the complete infection subsides. However, the benznidazole tablets should not be stopped suddenly and the duration of the treatment should be completed as prescribed.
• Do not take smaller or larger amounts of benznidazole tablets but take exactly as prescribed by the physician.
Dosage & When it is to be taken
• Benznidazole of 12.5 mg and 100 mg tablets are prescribed depending on the patient's body weight.• The prescribed dose is 5 mg/kg to 8 mg/kg taken orally in two divided doses (every 12 hourly) for a period of 60 days.
When it is not to be taken (Contraindications)
Benznidazole is not recommended in patients with• Allergy to benznidazole
• Pregnancy and breastfeeding as it cause teratogenicity
• Kidney or liver disease since it has not been evaluated in these patients
• Consumption of alcohol or products containing propylene glycol. Alcohol should be avoided for at least three days after completion of benznidazole treatment
• Disulfiram therapy taken within two weeks before starting benznidaloze treatment
