• Abemaciclib comes as a tablet which should be taken by mouth with or without food.
• Take abemaciclib tablets around the same time every day and exactly as advised.
• Swallow abemaciclib tablets with sufficient quantity of water and do not break, chew or crush the tablet.
• The recommended dose of abemaciclib is 200 mg twice a day
Combination therapy:
• The recommended dose of abemaciclib in combination therapy is 150 mg twice daily.
• Fulvestrant can be used in a recommended dose of 500 mg on days 1, 15, and 29 followed by once a month thereafter.
The treatment with abemaciclib should be continued until the progression of the disease or any unacceptable toxicity and dose modifications are recommended while serious adverse reactions occur.
The dose can be reduced by 50 mg after the occurrence of each grade of adverse reactions and the treatment with abemaciclib should be discontinued if the patient cannot tolerate 50 mg dose given twice a day.
Patients with severe liver disease should receive the tablet once daily.
• Allergy to abemaciclib
• Pregnancy and breastfeeding
• Take abemaciclib tablets around the same time every day and exactly as advised.
• Swallow abemaciclib tablets with sufficient quantity of water and do not break, chew or crush the tablet.
Dosage & When it is to be taken
Monotherapy:• The recommended dose of abemaciclib is 200 mg twice a day
Combination therapy:
• The recommended dose of abemaciclib in combination therapy is 150 mg twice daily.
• Fulvestrant can be used in a recommended dose of 500 mg on days 1, 15, and 29 followed by once a month thereafter.
The treatment with abemaciclib should be continued until the progression of the disease or any unacceptable toxicity and dose modifications are recommended while serious adverse reactions occur.
The dose can be reduced by 50 mg after the occurrence of each grade of adverse reactions and the treatment with abemaciclib should be discontinued if the patient cannot tolerate 50 mg dose given twice a day.
Patients with severe liver disease should receive the tablet once daily.
When it is not to be taken (Contraindications)
Abemaciclib should not be used in patients with-• Allergy to abemaciclib
• Pregnancy and breastfeeding
