Clozapine Interaction with Food, Herbs, Alcohol & Caffeine

Clozapine Interactions with Food and Herbs

Tobacco: Avoid using tobacco products like cigarettes along with Clozapine as it may induce CYP1A2 and reduce the plasma level and efficacy of the drug ().

Cannabis:

Avoid using cannabis while taking Clozapine since it reduces its absorption, which can in turn affect its efficacy.
Concurrent use may increase the risk of depression and other unwanted side effects (2^✔ ✔Trusted Source
10 prescription drugs that do not mix well with marijuana

Go to source).

Clozapine Interactions with Alcohol

Consuming alcohol while taking Clozapine can result in adverse effects, including dizziness, drowsiness, depression, and impaired concentration. ().

Clozapine Interactions with Caffeine

Avoid intake of Clozapine along with caffeine-containing products like coffee, tea, cola, and chocolate, as it can inhibit CYP1A2 metabolism and cause unwanted side effects including confusion, dry mouth, headache, drowsiness, dizziness and palpitations ().

When and How to Take Clozapine

Clozapine is available in the form of a tablet, an orally disintegrating tablet and an oral suspension (liquid) to take orally (by mouth).
You may take it preferably once or twice a day with or without food.
Take the medication at the same time every day for better results.
Follow the directions exactly as given on the prescription label.
Stick to the recommended dose and do not skip the prescribed dose of medicine without consulting your doctor (5^✔ ✔Trusted Source
National Library of Medicine: Clozapine MedlinePlus Drug Information.

Go to source).

References

1. Ryan, Jessica (2019). Tobacco smoking and its potential drug interactions. https://pharmaceutical-journal.com/article/ld/tobacco-smoking-and-its-potential-drug-interactions
2. Naveed Saleh (2021). 10 prescription drugs that do not mix well with marijuana. https://www.mdlinx.com/article/10-prescription-drugs-that-don-t-mix-well-with-marijuana/1S30QA6pykiTLPdyD33Czu
3. Yartsev, A., & Peisah, C. (2021). Caffeine-clozapine interaction associated with severe toxicity and multiorgan system failure: a case report. BMC psychiatry, 21(1), 192. doi:10.1186/s12888-021-03199-x
4. National Institute on Alcohol and Alcoholism. (2014) Harmful Interactions: Mixing Alcohol With Medicines. https://www.niaaa.nih.gov/publications/brochures-and-fact-sheets/harmful-interactions-mixing-alcohol-with-medicines
5. National Library of Medicine: Clozapine MedlinePlus Drug Information. https://medlineplus.gov/druginfo/meds/a691001.html#