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Food and Herbs Interaction with Cisapride


Are you taking Cisapride? Are you aware of the dangers of combining Cisapride with certain foods and herbs? Drug-food-interactions are seldom discussed but can lead to undesirable side effects and potentially diminish the efficacy of the medication.

Cisapride Interactions with Food and Herbs

Grapefruit: The interaction of grapefruit juice with Cisapride inhibits CYP3A4-mediated first pass metabolism and increases the plasma drug concentration (1 Trusted Source
Kivisto KT, Lilja JJ, Backman JT, Neuvonen PJ. Repeated consumption of grapefruit juice considerably increases plasma concentrations of cisapride. Clin Pharmacol Ther. 1999 Nov;66(5):448-53. doi: 10.1016/S0009-9236(99)70007-X. PMID: 10579471.

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).

When and How to Take Cisapride

  • Cisapride is available in the form of a tablet and a capsule to be taken orally.
  • It is usually taken four times a day, 15 minutes before meals and at bedtime.
  • Follow the directions exactly as given on the prescription label.
  • Take the medication at around the same time every day for better results.
  • Do not exceed or skip a dose. If you miss a dose, take the medication as soon as you remember.
  • Do not double the dose at a time to compensate for a missed dose (2 Trusted Source
    National Library of Medicine: Cisapride MedlinePlus Drug Information.

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    ).

References

1. Kivisto KT, Lilja JJ, Backman JT, Neuvonen PJ. Repeated consumption of grapefruit juice considerably increases plasma concentrations of cisapride. Clin Pharmacol Ther. 1999 Nov;66(5):448-53. doi: 10.1016/S0009-9236(99)70007-X. PMID: 10579471.
2. National Library of Medicine: Cisapride MedlinePlus Drug Information. https://medlineplus.gov/druginfo/meds/a694006.html

Drug Name : Cisapride

Cisapride is a gastroprokinetic agent, prescribed for nighttime heartburn.
We recommend consulting your doctor to verify the information presented on this page or if you need any further clarifications.


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