Are you taking Aliskiren? Are you aware of the dangers of combining Aliskiren with certain foods and herbs? Drug-food-interactions are seldom discussed but can lead to undesirable side effects and potentially diminish the efficacy of the medication.
Orange and apple juice greatly reduce the plasma concentrations of the OATP2B1 substrate aliskiren
Go to source)(2✔ ✔Trusted Source
Grapefruit juice greatly reduces the plasma concentrations of the OATP2B1 and CYP3A4 substrate aliskiren
Go to source).
References
Aliskiren Interactions with Food and Herbs
Fruit Juices: Fruit juices like grapefruit juice, orange juice, and apple juice should be avoided while taking aliskiren as they may reduce its bioavailability(1✔ ✔Trusted SourceOrange and apple juice greatly reduce the plasma concentrations of the OATP2B1 substrate aliskiren
Go to source)(2✔ ✔Trusted Source
Grapefruit juice greatly reduces the plasma concentrations of the OATP2B1 and CYP3A4 substrate aliskiren
Go to source).
When and How to Take Aliskiren
- Aliskiren is available in the form of an oral tablet.
- It is normally taken once a day with or without food.
- Take the tablet at the same time every day.
- Never take more or less of the medication than your doctor has advised(3✔ ✔Trusted Source
Aliskiren: MedlinePlus Drug Information
Go to source).
References
- Orange and apple juice greatly reduce the plasma concentrations of the OATP2B1 substrate aliskiren (https://pubmed.ncbi.nlm.nih.gov/21204914/)
- Grapefruit juice greatly reduces the plasma concentrations of the OATP2B1 and CYP3A4 substrate aliskiren (https://pubmed.ncbi.nlm.nih.gov/20664534/)
- Aliskiren: MedlinePlus Drug Information (https://medlineplus.gov/druginfo/meds/a607039.html)
