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Dabunase is an enzyme (thrombolytic agent), prescribed for deep vein thrombosis, heart attack, pulmonary embolism and peripheral vascular occlusion. It dissolves blood clots. 

Drug information on Dabunase (Urokinase) from Dabur Pharma Limited


Dabur Pharma Limited
Generic : Urokinase
2.5 lac iu/vial
1 Vial
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Medical Condition(s) for which Dabunase may be prescribed

Side effects of Dabunase

  Most Common: Severe bleeding.

  Heart : Heart attack, recurrent blood clot in lungs, stroke.

  Blood: Decreased red blood cells and platelets.

  Miscellaneous: Excess sweating.

  Potentially Fatal: Severe bleeding, severe allergic reactions, cholesterol embolization. Other side effects such as heart arrest and irregular heart rate have also been seen in patients taking urokinase.

Dosage & When it is to be taken (Indications)

Adult: IV- Deep vein thrombosis; Pulmonary embolism: Initial: 4,400 u/kg over 10 minutes, then 4,400 u/kg/hr for 12-24 hour (deep vein thrombosis) or 12 hour (pulmonary embolism).
Peripheral arterial thromboembolism: As 2,000 u/ml solution: Infuse into a clot via a catheter at a rate of 4,000 u/min for 2 hour.
Heart Attack: 2.5 lac IU over 10 minutes followed by 5 lac IU over the next 1 hour.

How to use Dabunase?

It comes as a solution for injection to be injected by a healthcare provider into the vein.

When is Dabunase not to be taken? (Contraindications)

Contraindicated in patients with active internal bleeding; history of stroke; recent (within 2 month) trauma including surgery on brain and spinal cord; aneurysm or tumor within the brain; known bleeding diathesis; severe uncontrolled high blood pressure, allergy to the drug.

Warnings and Precautions for Dabunase

Any vascular punctures or invasive procedures should be avoided.

•Caution needed for patients with history of peptic ulcer disease, pre-existing bleeding disorders, high blood pressure, heart infection, recent biopsy or surgery, recent injury, any allergies.

• Use extra caution to avoid injury and trauma. Use with caution in patients with liver or kidney disease, coagulation defects, brain disease, damage to the retina due to diabetes or any other condition in which bleeding could be dangerous, pregnancy or after recent surgery, childbirth or trauma.

•Monitor for reperfusion heart rate when used in heart attack.

•It may increase the risk of cerebral bleeding.

Other Precautions for Dabunase

Blood tests including hematocrit, platelet count and activated partial thromboplastin time should be checked.

Storage Conditions for Dabunase

Injection: Store below 25°C. Store it in room temperature, and in an airtight container.

Schedule : H  Prescription drugs - Drugs to be sold only under the prescription of a Registered Medical Practitioner.

Disclaimer : The Price of the drugs indicated above may not match the actual price at which they are sold. Prices can change depending on many factors, including GST. These are only approximate indicative prices of the drug.
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