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Drug information on Kolibitor (Trimethoprim) from Fusion Health Care Pvt. Ltd.


Fusion Health Care Pvt. Ltd.
Generic : Trimethoprim
1 Vial
Update the Drug Info

Drug Name : Trimethoprim

Trimethoprim generic Trimethoprim is prescribed to treat bacterial infections, mainly uncomplicated urinary tract infections It blocks the synthesis of tetrahydrofolate, the active form of folic acid, and therefore inhibits the growth of bacteria. Since it is an antibacterial, trimethoprim is ineffective and should not be used to treat viral infections such as common cold or flu. Trimethoprim is also used to treat middle ear infections or otitis mediaIt is used along with sulfamethoxazole or sulfadiazine for the treatment of several other bacterial infections.
More Info about Trimethoprim

Vijayaganesh Kasinathan
Written & Compiled by Pharmacist Vijayaganesh Kasinathan, B.Pharm, M.Pharm
Dr. Simi Paknikar
Medically Reviewed by Dr. Simi Paknikar, MD
Last Updated on Sep 23, 2017

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Medical Condition(s) for which Kolibitor may be prescribed

Overview of Kolibitor

Trimethoprim is an antibacterial which is used to treat various bacterial infections particularly for the infections occurring in the urinary tract.

Side effects of Kolibitor

  Skin: Rashes, itching, photosensitivity (sensitivity of the skin to sunlight), rarely serious skin reactions like Stevens Johnson syndrome and epidermal necrolysis.

  Gastrointestinal System: Nausea, vomiting, glossitis and gastrointestinal discomfort, diarrhea.

  Liver: Alterations in liver enzymes, cholestatic jaundice (rare).

  Blood: Reduced blood counts, megaloblastic anemia.

  Others: Muscle aches, headache, fever, aseptic meningitis, increased serum creatinine and blood urea nitrogen levels (which could indicate reduced kidney function).

Dosage & When it is to be taken (Indications)

For urinary tract infections:
• The recommended adult dosage is either 100 mg twice daily for 20 days or 200 mg once daily for ten days.
• For the prevention of recurrent urinary tract infection, it is administered as 100mg once daily at night to ensure maximum urinary concentrations.

For treating Otitis media in children:
• In children 6 months or older, the usual dosage is 5mg/kg orally twice daily for ten days.

How to use Kolibitor?

Trimethoprim comes as a tablet and an oral solution and can be taken on a full or empty stomach. In case of gastrointestinal discomfort, it can be taken along with food.

When is Kolibitor not to be taken? (Contraindications)

Trimethoprim is contraindicated in the following conditions:
• Patients with megaloblastic anemia. Megaloblastic anemia occurs due to folic acid deficiency. Therefore, trimethoprim can worsen the condition.
• Pregnancy, especially in the first trimester due to its interference with folic acid metabolism. Adequate supplementation should be provided in case it is unavoidable.
• Patients allergic to the drug.

Warnings and Precautions for Kolibitor

• Culture and sensitivity tests should be carried out to know about the susceptibility of the bacterial species to this drug.
• Use with caution in individuals with kidney or liver impairment.

Other Precautions for Kolibitor

• Reduced blood counts may occur in patients on long-term therapy.
• The blood counts should be monitored regularly in these patients.

Drug Interactions of Kolibitor

Diuretics: Trimethoprim when taken with some diuretics may increase the risk of low platelet counts and high potassium levels; rare cases of low sodium levels has been reported.
Rifampicin: Rifampicin increases the elimination of trimethoprim.

Trimethoprim may increase the plasma concentration of drugs like phenytoin, digoxin, repaglinide and anticoagulants.

Storage Conditions for Kolibitor

• Store in a dry place and at a room temperature below 25°C.
• Keep out of the reach of children.

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For the above reasons Medindia cannot be held liable for any action taken based on the information provided by its website. The purpose of this website is to only provide the initial guidance and it does not intend to replace professional medical opinion in any manner whatsoever.

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