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Drug information on Bactrim (100mg/20mg) (Sulphamethoxazole 100mg + Trimethoprim 20mg) from AHPL

Bactrim (100mg/20mg)

  Pediatric Tablet
Generic : Trimethoprim
Combination of Generics : Sulphamethoxazole 100mg + Trimethoprim 20mg

Drug Name : Trimethoprim

Trimethoprim generic Trimethoprim is prescribed to treat bacterial infections, mainly uncomplicated urinary tract infections It blocks the synthesis of tetrahydrofolate, the active form of folic acid, and therefore inhibits the growth of bacteria. Since it is an antibacterial, trimethoprim is ineffective and should not be used to treat viral infections such as common cold or flu. Trimethoprim is also used to treat middle ear infections or otitis mediaIt is used along with sulfamethoxazole or sulfadiazine for the treatment of several other bacterial infections.
More Info about Trimethoprim

Vijayaganesh Kasinathan
Written & Compiled by Pharmacist Vijayaganesh Kasinathan, B.Pharm, M.Pharm
Dr. Simi Paknikar
Medically Reviewed by Dr. Simi Paknikar, MD
Last Updated on Sep 23, 2017
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Side effects of Trimethoprim

  Skin: Rashes, itching, photosensitivity (sensitivity of the skin to sunlight), rarely serious skin reactions like Stevens Johnson syndrome and epidermal necrolysis.

  Gastrointestinal System: Nausea, vomiting, glossitis and gastrointestinal discomfort, diarrhea.

  Liver: Alterations in liver enzymes, cholestatic jaundice (rare).

  Blood: Reduced blood counts, megaloblastic anemia.

  Others: Muscle aches, headache, fever, aseptic meningitis, increased serum creatinine and blood urea nitrogen levels (which could indicate reduced kidney function).

When is Trimethoprim not to be taken? (Contraindications)

Trimethoprim is contraindicated in the following conditions:
• Patients with megaloblastic anemia. Megaloblastic anemia occurs due to folic acid deficiency. Therefore, trimethoprim can worsen the condition.
• Pregnancy, especially in the first trimester due to its interference with folic acid metabolism. Adequate supplementation should be provided in case it is unavoidable.
• Patients allergic to the drug.

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