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Topgraf is an immunosupressant, prescribed for preventing organ rejection during transplantation. It decreases the activity of immune system to prevent an organ from rejection. 

Drug information on Topgraf (Tacrolimus) from Glaxo SmithKline Pharmaceuticals Ltd.

Topgraf

  Ointment   
Glaxo SmithKline Pharmaceuticals Ltd.
Generic : Tacrolimus
 108.35
0.03% w/w
10 g
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Medical Condition(s) for which Topgraf may be prescribed


Side effects of Topgraf

   Gastrointestinal : Loss of appetite, constipation, dehydration, gastrointestinal disorder, rectal disorder, hernia, intestinal inflammation, mouth ulcer and infection.

   Central Nervous System : Anxiety, dizziness, increased muscle tone, abnormal thinking, uneasiness and headache.

   Heart : Vein inflammation, heart disease, dilatation of blood vessels, fainting, fast heart rate and chest pain.

   Skin : Photosensitivity reaction, skin cancer, skin discoloration, skin overgrowth, skin ulcer, white patches on the skin and sweating.

   Eye and ENT : Abnormal vision, eye swelling, taste perversion, tooth decay, dry eyes, ear disorder, nosebleed and eye pain.

   Respiratory : Difficulty in breathing, lung disorder and inflammation of larynx.

   Metabolic : Increased cholesterol level and over active thyroid.

   Musculoskeletal : Joint inflammation, tendon disorder, nail disorder, neck pain and joint disorder.

   Genitourinary : Unintended pregnancy and vaginal infection/inflammation.

  Blood:Anemia.

   Miscellaneous : Chills, fungal infection and swelling in the extremities.

Dosage & When it is to be taken (Indications)

Topical- As 0.03% ointment- Apply a thin layer over the affected skin twice daily.

How to use Topgraf?

It comes as an ointment to apply topically as directed by your physician.

When is Topgraf not to be taken? (Contraindications)

Hypersensitivity.

Warnings and Precautions for Topgraf

Caution should be exercised in patients with heart, kidney or liver disease, any allergy, who are taking other medications, elderly, children, during pregnancy and breastfeeding.

• Patient may develop with increased risk of skin cancer; avoid exposure to sunlight.

• Wear protective clothing and sunscreen with a high skin protection factor (SPF) to avoid sunburn.

• Wear sunglasses avoid eye damage.

• It may increase blood pressure; monitor blood pressure level regularly while taking this medication.

• Patient may experience with the following symptoms: thirst, excessive hunger, frequent urination, blurred vision and confusion.

• Avoid vaccination while taking this medication.

Other Precautions for Topgraf

Avoid excess dosage.

Storage Conditions for Topgraf

Store it at room temperature (25°C).

♦ Safety Labeling Changes Approved By FDA



Disclaimer : The Price of the drugs indicated above may not match the actual price at which they are sold. Prices can change depending on many factors, including GST. These are only approximate indicative prices of the drug.
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