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Drug information on Sulphadimidine (500mg) (Acichem Labs) (Sulfadimidine) from Acichem Laboratories

Sulphadimidine (500mg) (Acichem Labs)

Acichem Laboratories
Generic : Sulfadimidine
1000 Tablets

Drug Name : Sulfadimidine

Sulfadimidine generic Sulfadimidine is prescribed to treat urinary tract infections, prostatitis (infection of the prostate gland) and respiratory tract infections caused by bacteria. It is capable of inhibiting the growth or reproduction of bacteria but not killing the bacteria. It blocks the synthesis of bacterial dihydrofolic acid and therefore inhibits the growth of bacteria.
More Info about Sulfadimidine

Vijayaganesh Kasinathan
Written & Compiled by Pharmacist Vijayaganesh Kasinathan, B.Pharm, M.Pharm
Dr. Simi Paknikar
Medically Reviewed by Dr. Simi Paknikar, MD
Last Updated on Oct 09, 2017
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Medical Condition(s) for which Sulphadimidine (500mg) (Acichem Labs) may be prescribed

Overview of Sulphadimidine (500mg) (Acichem Labs)

• Sulfadimidine is a short-acting antibacterial agent.
• These medicines are grouped under synthetic antimicrobial agents that contain the sulfonamide group.
• These are commonly called as sulfa drugs.

Side effects of Sulphadimidine (500mg) (Acichem Labs)

  Skin: Allergic reactions such as rashes, itching and rarely causes serious skin reactions like Stevens-Johnson-Syndrome and epidermal necrolysis.

  Gastrointestinal: Diarrhea, nausea and vomiting.

  Blood: Anemia, agranulocytosis (low white blood cell count), hemolytic anemia (anemia that occurs due to the rupture of red blood cell) and thrombocytopenia (reduced platelet count) in patients with glucose-6-phosphate deficiency.

  Others: Crystalluria (cloudy urine), pancreatitis, hepatitis, cholestatic jaundice, and fever.

Dosage & When it is to be taken (Indications)

• The recommended adult dose is 0.5 g to 1 g taken three or four times daily.

How to use Sulphadimidine (500mg) (Acichem Labs)?

• Sulfadimidine comes as a tablet or suspension to be taken by mouth with food to avoid gastric discomfort.
• Antacids reduce the absorption of sulfadimidine, therefore antacids should be taken after 2 hours from sulfadimidine administration.

When is Sulphadimidine (500mg) (Acichem Labs) not to be taken? (Contraindications)

• Sulfadimidine should not be used in patients suffering from porphyria, a disorder with an excess chemical called porphyrin that affects nervous system and skin.
• It is not recommended in kidney failure patients because the drug is rapidly excreted in urine.
• Patients with G6PD (glucose 6 phosphate dehydrogenase) deficiency should not take sulfadimidine because of the occurrence of blood disorders such as anemia, agranulocytosis, hemolytic anemia and thrombocytopenia.
• It should not be used in patients allergic to the drug.

Warnings and Precautions for Sulphadimidine (500mg) (Acichem Labs)

Caution is needed in newborns as sulfadimidine induces jaundice by displacing bilirubin (bile pigment) from its binding protein.

• Use with caution in individuals with kidney or liver disease.

Other Precautions for Sulphadimidine (500mg) (Acichem Labs)

• A complete blood cell count should be monitored during the therapy to detect for various blood disorders.

Drug Interactions of Sulphadimidine (500mg) (Acichem Labs)

• Drugs such as ascorbic acid increase the risk of crystalluria.
• The toxicity of methotrexate is increased by sulfadimidine.
• Metabolism of phenytoin, tolbutamide, and warfarin are inhibited by sulfadimidine resulting in accumulation of these drugs in the body.
Clozapine, an antipsychotic drug taken together with sulfadimidine could increase the chances of blood problems.

Storage Conditions for Sulphadimidine (500mg) (Acichem Labs)

• Stored at room temperature away from light and moisture.
• Keep out of reach of children.

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