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Rapamune is an immunosuppressant, prescribed for preventing rejection of kidney transplants either alone or with other medications. It works by suppressing the body's immune system.

Drug information on Rapamune (Sirolimus) from Wyeth Limited


Wyeth Limited
Generic : Sirolimus
30 Tablets
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Medical Condition(s) for which Rapamune may be prescribed

Side effects of Rapamune

   Most Common : Swelling in the extremities, high blood pressure, increased cholesterol level, constipation, abdominal pain, diarrhea, headache, fever, urinary tract infection, anemia, nausea, joint pain, and decrease in platelet counts.

   Body as a Whole : Sepsis and infections.

   Heart : Blood clot events and fast heart rate.

   Gastrointestinal : Mouth ulcer.

  Metabolic: Abnormal healing, increased level of lactic dehydrogenase (LDH) and decrease in blood potassium level.

   Musculoskeletal : Death of bone cells.

   Respiratory : Nose bleed and lung infection.

   Skin : Skin cancer and rash.

   Genitourinary : Kidney inflammation.

Dosage & When it is to be taken (Indications)

Adult: PO- Low-moderate risk patients: 6 mg on day 1. Maintenance: 2 mg once daily, given 4 hour after ciclosporin.
High immunological risk patients: Recommended loading dose: 15 mg. Maintenance: 5 mg/day.

How to use Rapamune?

It comes as a tablet to take by mouth, on an empty stomach or with food.

When is Rapamune not to be taken? (Contraindications)


Warnings and Precautions for Rapamune

Caution should be exercised in patients with history of liver, kidney problems, high cholesterol, low blood platelet levels, diabetes, lung or breathing problems, any allergy, infections, who are taking other medications especially for HIV or Hepatitis C , during pregnancy and breastfeeding.

• Avoid contact with people who have infections.

• Patient may develop with increased risk of progressive multifocal leukoencephalopathy (PML), severe kidney problems, certain types of cancer; if it is so consult with your doctor.

• Avoid live vaccination while taking this medication.

• It may affect blood sugar level; monitor sugar level regularly while taking this medication.

Other Precautions for Rapamune

Avoid excess dosage.

Storage Conditions for Rapamune

Store it at room temperature (25°C), and in an airtight container.

♦ Safety Labeling Changes Approved By FDA

Disclaimer : The Price of the drugs indicated above may not match the actual price at which they are sold. Prices can change depending on many factors, including GST. These are only approximate indicative prices of the drug.
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Substitutes for Rapamune

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