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Maladex is an antimalarial agent, prescribed for treatment of falciparum malaria, resistant to chloroquine. It blocks the formation of folinic acid within the malaria organism, which kills the parasite.  

Drug information on Maladex (Pyrimethamine, Sulphamethopyrazine) from Bestochem Formulations (India) Ltd.

Maladex

  Tablet  
Bestochem Formulations (India) Ltd.
Generic : Pyrimethamine- Sulfadoxine
 6.25
500mg/25mg
2 Tablets
Combination of Generics : Pyrimethamine, Sulphamethopyrazine
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Side effects of Pyrimethamine- Sulfadoxine

  Blood: Decrease in white blood cells, bone marrow depression, decrease in platelets, anemia, bruising, poor blood clot, methemoglobinemia, and increase in eosinophils.

  Allergic Reactions: Rash, itching, swelling, dizziness, trouble breathing.

  Skin: Severe allergic reactions, hair loss.

   Eye: Photosensitivity, swelling in the eye.

  Gastrointestinal : Inflammation of tongue, mouth infection, nausea, vomiting, abdominal pains, diarrhea, inflammation of liver or pancreas, feeling of fullness, and transient rise of liver enzymes.

  Central Nervous System : Depression, headache, hallucinations, fatigue, nervousness, fainting. Sleeplessness, inflammation of nerves, involuntary movements, emotion, muscle weakness.

  Respiratory: Pulmonary infiltrates resembling eosinophilic or lung inflammation.

  Genitourinary: Kidney failure, interstitial nephritis, decreased urination, and crystals in urine.

  Miscellaneous : Drug fever, chills, and LE phenomenon have occurred.

When is Pyrimethamine- Sulfadoxine not to be taken? (Contraindications)

Contraindicated in patients with severe kidney or liver failure, blood disorder, hypersensitivity to components, megaloblastic anemia due to folic acid deficiency, pregnancy at term and during lactation, infants ≤ 2 month old.


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Disclaimer : The Price of the drugs indicated above may not match the actual price at which they are sold. Prices can change depending on many factors, including GST. These are only approximate indicative prices of the drug.
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Substitutes for Pyrimethamine- Sulfadoxine

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