Email bookmark
Font : A-A+

Prothionamide is prescribed to treat multidrug-resistant tuberculosis (MDR TB) and given as part of a treatment regime, usually involving 5 medicines.

It is also used to treat tuberculous meningitis in adults and children.

Prothionamide is a thioamide, structurally similar to ethionamide and clinically interchangeable with it. 

Drug information on Pethide (250mg) (Prothionamide) from Lupin Laboratories Ltd.

Pethide (250mg)

Lupin Laboratories Ltd.
Generic : Prothionamide
10 Tablets
Medindia currently has information on 3063 generic drugs and 110,042 brands that have their prices listed. New drugs with their prices are listed as and when they get approved by the drug controller. Please do write to us ( if a drug is missing from our comprehensive drug price list.

Medical Condition(s) for which Pethide (250mg) may be prescribed

Overview of Pethide (250mg)

Prothionamide is a thioamide that forms an important component in multidrug-resistant tuberculosis treatment regimens in adults and children.

Side effects of Pethide (250mg)

  Gastrointestinal:Excessive salivation, metallic taste, nausea, vomiting, abdominal pain, anorexia, diarrhea and inflammation of the mouth

  Central nervous system: Depression, drowsiness, encephalopathy, peripheral neuropathy, headache, restlessness, anxiety, psychotic disturbances

  Liver: Transient increases in Liver Function Test parameters, acute hepatitis (rare)

  Metabolic: Hypothyroidism, gynecomastia, hypoglycemia

Dosage & When it is to be taken (Indications)

The recommended dose for prothionamide is

Adults: 15-20 mg/kg/day that amounts to around 500-750 mg per day; maximum dose per day should not exceed 1000 mg or 1 gram
Children: 15-20 mg/kg/day with a maximum daily dose of 1000 mg

How to use Pethide (250mg)?

• Prothionamide should be taken orally.

• Adults and children can take it as one dose to maximize peak levels (particularly for daily doses less than 750 mg) if they can tolerate it.

• The dose can be split into two if once a day dose is not tolerated.

• Dose may have to be gradually escalated for adults. Increase dose by 250 mg every 3 to 5 days.

• Take with or after meals to reduce gastrointestinal adverse effects.

When is Pethide (250mg) not to be taken? (Contraindications)

• Prothionamide is contraindicated in patients with known allergy to the drug.

• Prothionamide is also contraindicated in pregnant and lactating women and in patients who have severe renal disease and porphyria.

Warnings and Precautions for Pethide (250mg)

Complete the entire dose of the drug.

• Pyridoxine should be prescribed along with prothionamide (adult doses from 50 to 100 mg daily, up to 50 mg per 250 mg of prothionamide).

Other Precautions for Pethide (250mg)

• Thyroid function tests have to be taken once in 3 months when taking prothionamide.

• Blood sugar levels must be monitored in diabetic patients.

Drug Interactions of Pethide (250mg)

Prothionamide could cause adverse effects when given along with

• Cycloserine (increased risk of neurotoxicity).
• Isoniazid (increased serum concentrations).
• P-aminosalicylic acid (increased risk of hypothyroidism).
• Rifampicin and thiacetazone (increased risk of hepatotoxicity).

Storage Conditions for Pethide (250mg)

Prothionamide should be stored at room temperature.

Disclaimer : The Price of the drugs indicated above may not match the actual price at which they are sold. Prices can change depending on many factors, including GST. These are only approximate indicative prices of the drug.
Buy Medicines (Drug) at Concessional Price from India
Substitutes for Pethide (250mg)

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.