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Prothionamide is prescribed to treat multidrug-resistant tuberculosis (MDR TB) and given as part of a treatment regime, usually involving 5 medicines.

It is also used to treat tuberculous meningitis in adults and children.

Prothionamide is a thioamide, structurally similar to ethionamide and clinically interchangeable with it. 

Drug information on Mdpride (250mg) (Prothionamide) from Maneesh Pharmaceuticals Ltd

Mdpride (250mg)

  Tablet  
Maneesh Pharmaceuticals Ltd
Generic : Prothionamide
 31.00
250mg
4 Tablets
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Medical Condition(s) for which Mdpride (250mg) may be prescribed


Overview of Mdpride (250mg)

Prothionamide is a thioamide that forms an important component in multidrug-resistant tuberculosis treatment regimens in adults and children.

Side effects of Mdpride (250mg)

  Gastrointestinal:Excessive salivation, metallic taste, nausea, vomiting, abdominal pain, anorexia, diarrhea and inflammation of the mouth

  Central nervous system: Depression, drowsiness, encephalopathy, peripheral neuropathy, headache, restlessness, anxiety, psychotic disturbances

  Liver: Transient increases in Liver Function Test parameters, acute hepatitis (rare)

  Metabolic: Hypothyroidism, gynecomastia, hypoglycemia

Dosage & When it is to be taken (Indications)

The recommended dose for prothionamide is

Adults: 15-20 mg/kg/day that amounts to around 500-750 mg per day; maximum dose per day should not exceed 1000 mg or 1 gram
Children: 15-20 mg/kg/day with a maximum daily dose of 1000 mg

How to use Mdpride (250mg)?

• Prothionamide should be taken orally.

• Adults and children can take it as one dose to maximize peak levels (particularly for daily doses less than 750 mg) if they can tolerate it.

• The dose can be split into two if once a day dose is not tolerated.

• Dose may have to be gradually escalated for adults. Increase dose by 250 mg every 3 to 5 days.

• Take with or after meals to reduce gastrointestinal adverse effects.

When is Mdpride (250mg) not to be taken? (Contraindications)

• Prothionamide is contraindicated in patients with known allergy to the drug.

• Prothionamide is also contraindicated in pregnant and lactating women and in patients who have severe renal disease and porphyria.

Warnings and Precautions for Mdpride (250mg)

Complete the entire dose of the drug.

• Pyridoxine should be prescribed along with prothionamide (adult doses from 50 to 100 mg daily, up to 50 mg per 250 mg of prothionamide).

Other Precautions for Mdpride (250mg)

• Thyroid function tests have to be taken once in 3 months when taking prothionamide.

• Blood sugar levels must be monitored in diabetic patients.

Drug Interactions of Mdpride (250mg)

Prothionamide could cause adverse effects when given along with

• Cycloserine (increased risk of neurotoxicity).
• Isoniazid (increased serum concentrations).
• P-aminosalicylic acid (increased risk of hypothyroidism).
• Rifampicin and thiacetazone (increased risk of hepatotoxicity).

Storage Conditions for Mdpride (250mg)

Prothionamide should be stored at room temperature.



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Substitutes for Mdpride (250mg)

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