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Drug information on Neozine (Procarbazine) from Alkem Laboratories Ltd. (Cytomed)


Alkem Laboratories Ltd. (Cytomed)
Generic : Procarbazine
50 Capsules
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Drug Name : Procarbazine

Procarbazine(Matulane) generic Neozine is an antineoplastic agent, prescribed for Hodgkin disease. It inhibits protein, RNA, and DNA synthesis that help to stop the cancer cell growth.
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Other Trade Names for Procarbazine

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Written & Compiled by Anushta Chandrapalan, M.Sc  | Medically Reviewed by The Medindia Medical Review Team on Mar 30, 2018

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Medical Condition(s) for which Neozine may be prescribed

Side effects of Neozine

   Blood : Nose bleed, bruising, anemia and eosinophilia.

   Gastrointestinal : Liver dysfunction, jaundice, mouth ulcer, blood vomiting, blood in stool, diarrhea, indigestion, loss of appetite, abdominal pain, constipation and dry mouth.

   Central Nervous System : Coma, convulsions, nerve disease, incoordination, tingling, night blindness, diminished reflexes, falling, foot drop, headache, dizziness and unsteadiness.

   Heart : Low blood pressure, fast heart rate and fainting.

   Eye : Eye bleeding, sensitivity to light, double vision, optic disc swelling and inability to focus.

   Respiratory : Lung inflammation/infection and increased cough.

   Skin : Skin inflammation, itching, hair loss, pigmentation, rash, hives and flushing.

   Allergic reactions : Generalized allergic reactions.

   Genitourinary : Blood in urine, urinary frequency, nighttime urination and breast enlargement in male.

   Musculoskeletal : Pain, including muscle and joint pain and tremors.

   Psychiatric : Hallucinations, depression, apprehension, nervousness, confusion and nightmares.

   Miscellaneous : Infections, hearing loss, fever, increased sweating, lethargy, weakness, fatigue, edema, chills, sleeplessness, slurred speech, hoarseness and drowsiness.

Dosage & When it is to be taken (Indications)

Adult: The recommended dose is 2–4 mg/kg/day either in a single dose or divided, given for 7 days then increased to 4–6 mg/kg/day.

How to use Neozine?

It comes as a capsule to take by mouth, with or without food.

When is Neozine not to be taken? (Contraindications)

Contraindicated in patients with bone marrow depression and hypersensitivity.

Warnings and Precautions for Neozine

Caution should be exercised in patients with history of congestive heart failure, adrenal gland tumors (eg, pheochromocytoma), bone marrow depression, heart disease, frequent headaches, mental problems, kidney, or liver disease, any allergy, who are taking other medications, during pregnancy and breastfeeding.

• It may cause drowsiness or dizziness, do not drive a car or operate machinery while taking this medication.

• Avoid exposure to sunlight.

• It may reduce platelet counts, avoid bruising or injury.

Other Precautions for Neozine

Avoid excess dosage.

Storage Conditions for Neozine

Store it at room temperature.

Schedule : G  Drugs that are to be used only under medical supervision.

Disclaimer : updates the prices regularly, however despite that there may be discrepancies in the prices displayed. This can be due to many reasons including -
  • Difference in GST/local taxes
  • Change in price by the company
  • Updation of information may not have happened at the right time
For the above reasons Medindia cannot be held liable for any action taken based on the information provided by its website. The purpose of this website is to only provide the initial guidance and it does not intend to replace professional medical opinion in any manner whatsoever.

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