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Pirfetab 200mg (Pirfenidone) Drug Price and Information

pirfenidone (Pirfetab 200mg) (Pirfetab 200mg) is prescribed for treating idiopathic pulmonary fibrosis which is a severe irreversible disease marked by a progressive decline in lung function. The scarring of lungs is caused by some unknown origin.
The exact mechanism of action of pirfenidone is not known. pirfenidone (Pirfetab 200mg) (Pirfetab 200mg) is thought to reduce the lung fibrosis (scarring and thickening of lungs) by decreasing the release or activity of naturally occurring substances in the body such as certain growth factors. 
The information provided on this page is intended to serve as a comprehensive resource and should not be a substitute to professional medical advice. If you have concerns it is always best to speak with a healthcare professional.

Pirfetab - Zydus Cadila Healthcare Ltd.

Pirfetab 200mg  Tablet  

Generic : Pirfenidone
Price Updated on August 8, 2019
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Drug information on Pirfetab 200mg from Zydus Cadila Healthcare Ltd.


When is Pirfetab 200mg prescribed?

It is prescribed for -

Overview of Pirfetab 200mg

Pirfenidone is a novel drug with anti-inflammatory and antifibrotic properties which improves lung function in idiopathic pulmonary fibrosis(IPF).


What should be the dose and frequency?

• The recommended daily maintenance dosage for adults is 801mg (3 capsules of 267mg each) three times a day to be taken with food.
• The maximum daily dosage should not exceed 2403mg.

In treating idiopathic pulmonary fibrosis, the dosage can be started as per the following schedule:

From day 1 to 7 - 1 capsule per day
From day 7 to 14 - 2 capsules per day
From day 15 - 3 capsules per day

• Patients who miss pirfenidone for 14 days or more should restart the treatment with initial 2 week schedule to reach the full maintenance dosage schedule that starts from day 15.
• Patients who miss less than 14 days, the dosage before the interruption can be continued. They should not take two doses at the same time and more than three doses per day.

What are the common side effects of Pirfetab 200mg

Gastrointestinal: Nausea, vomiting, gastritis, GERD (gastro oesophageal reflux disease), loss of appetite, indigestion, abdominal pain, abdominal distension

Skin: Photosensitivity, rash, itching and dry skin

Central Nervous System: Dizziness, insomnia, and fatigue

Respiratory: Sinusitis and upper respiratory infections

Others: Increased liver enzymes, joint pain, weight loss

How to use Pirfetab 200mg?

• Pirfenidone comes as a capsule to be taken by mouth.
• It is usually taken with food to avoid gastric discomfort.
• The capsules to be taken at the same time every day.


In which conditions should Pirfetab 200mg be avoided?

Pirfenidone is not recommended in patients with:

• End stage renal disease who require dialysis.
• Severe liver impairment or damage.

It is also contraindicated in patients taking fluvoxamine treatment.

What are the Precautions needed with Pirfetab 200mg

• Liver enzymes could increase during pirfenidone therapy. The levels to be monitored for either temporary dosage adjustment or discontinuation of the therapy.

• Rashes and sensitivity to sunlight, tanning beds and other fluorescent lamps can occur. Avoid direct sun exposure by using sunscreen (SPF- sun protection factor- 50 or even higher), protective clothing and sun glasses.

• The safety of pirfenidone in children is not known.

Are there any additional Precautions?

• Cigarette smoking during the therapy should be stopped as smoking causes increased clearance of drug from the body leading to decreased effectiveness of the drug.
• Increased calorie intake may be required in patients with excessive weight loss due to pirfenidone.

Drug Interactions of Pirfetab 200mg

Increase in the toxicity of pirfenidone may occur with the following drugs and hence their combined use with pirfenidone should be avoided.

• Anti depressants such as fluvoxamine, fluoxetine and paroxetine
• Antibiotics such as ciprofloxacin and chloramphenicol

Decrease in the circulating plasma levels of pirfenidone could occur with drugs such as omeprazole.

At What Temperature Should it be Stored?

• Store in a tightly closed container.
• Discard the medicine safely if the medicine is out of date or damaged.

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