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Drug information on Pamidronate Disod 30 Mg Vial (Pamidronate) from Sandoz Private Ltd.

Pamidronate Disod 30 Mg Vial   Injection Sandoz Private Ltd. Generic : Pamidronate	111.94 30mg 1vial

Information Checked by Dhanalakshmi Chinnuswamy, Diploma in Pharmacy, MBA (Healthcare)

Further Checked by The Medindia Medical Review Team on Oct 14, 2010

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Bone Metastases

Pagets And Jaw Bone Diseases

Pagets disease of the breast

•  General: Generalized pain, fever, reactivation of viral diseases. Flu-like reaction may occur initially.

•  Heart : High blood pressure, abnormal heart rate or rhythm, heart failure, syncope.

•  Central Nervous System: Confusion, visual hallucinations, electrolyte imbalance, sleeplessness, nervousness, drowsiness, mental or mood changes.

•  Gastrointestinal: Abdominal pain, loss of appetite, constipation, nausea, vomiting, diarrhea, mouth ulcer, gastrointestinal hemorrhage, osteonecrosis of jaw.

•  Genitourinary: Increased blood urea, renal tubular disorders (RTD).

•  Skin : Rash, itching.

•  Eye: Inflammation of eye tissues.

•  Blood: Decrease in red blood cells, white blood cells and platelets.

•  Metabolic: Low thyroid hormone, decrease in calcium, potassium, magnesium, phosphate level in blood.

♦•  Respiratory: Runny nose, upper respiratory infection, adult respiratory distress syndrome (ARDS and interstitial lung disease (ILD).

•  Musculoskeletal: Bone and muscle pain

Rare instances of allergic manifestations have been reported, including low blood pressure, difficulty in breathing, or angioedema, and, very rarely, anaphylactic shock.

Potentially Fatal: Acute kidney and heart failure.

Adult: IV- Paget's disease of bone- 30 mg/day for 3 consecutive days.
Hypercalcemia- 60 to 90mg, as single dose, over 2 to 24 hours.
Multiple Myeloma with bone disease- 90 mg administered as a 4-hour infusion given on a monthly basis.

It comes as a solution to inject into a vein, administered by a healthcare provider.

Contraindicated to pregnant women and patients with known hypersensitivity.

• Do not take calcium and vitamin D supplement if you have high blood calcium levels.

•If possible, avoid dental treatment while you are using this medication to prevent osteonecrosis of the jaw.

• It may increase the risk of heart failure in patients with heart disease.

•Inject slowly to reduce risk of adverse effects (e.g. injection site reactions, kidney impairment).

• ♦Monitor blood counts in patients with preexisting poor blood counts.

Patient may develop bone, muscle pain at anytime after starting this medication.

Injection: Store it at room temperature. After reconstitution: Stable for up to one day when refrigerated at 2-8°C.