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Drug information on Neotrexate (Methotrexate) from Glaxo SmithKline Pharmaceuticals Ltd.


Glaxo SmithKline Pharmaceuticals Ltd.
Generic : Methotrexate
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Drug Name : Methotrexate

Methotrexate generic Neotrexate is an antimetabolite, curative in choriocarcinoma (cancer of the tissue that normally would develop into placenta). It is also used in other cancers like blood, breast and lung cancers. It is also used to suppress immunity in conditions such as psoriasis and rheumatoid arthritis.
More Info about Methotrexate

Written & Compiled by Anushta Chandrapalan, M.Sc  | Medically Reviewed by The Medindia Medical Review Team on February, 2, 2017

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Medical Condition(s) for which Neotrexate may be prescribed

Side effects of Neotrexate

  Central Nervous System: Dizziness, fatigue, headache, language disorder, weakness, paresis, convulsions, destruction of the myelin sheaths (IV after cranio spinal irradiation), inflammation of the arachnoid (a covering of the brain), transient paresis, nerve damage.

  Skin: Redness of the skin, rashes, itching, loss of hair, hives, photosensitivity, pigmentary changes, skin discoloration, dilatation of blood vessels, acne, furunculosis, aggravation of psoriasis by ultraviolet light, severe allergic reactions.

  Eye and ENT: Blurred vision, inflammation of the gums, inflammation of pharynx.

  Gastrointestinal: Nausea, vomiting, enteritis, mouth ulcer, diarrhea, abdominal distress (common), loss of appetite, blood in vomit, blood in stool, GI ulceration and bleeding.

  Genitourinary: Renal failure, blood contains excess amount nitrogen, inflammation of the urinary bladder, blood in urine, severe kidney disease, reproductive disorders, infertility, abortion, fetal defects.

  Blood: Deficiency of all three blood cell types, bone marrow depression, anemia, bleeding, presence of bacteria in the blood (septicemia).

  Liver: Elevated LFTs (liver function test), liver damage.

  Respiratory: Deaths from interstitial pneumonia, chronic interstitial obstructive lung disease.

  Miscellaneous: Malaise, chills, fever, lower resistance to infections, joint pain, muscle pain, diabetes, osteoporosis, allergic reactions, sudden death.

Dosage & When it is to be taken (Indications)

Oral Burkitt's lymphoma- 10-25 mg/day for 4-8 days, repeat after 7-10 days.
Oral & IMChoriocarcinoma(Ectopic Pregnancy)- 15-30 mg/day for 5 days, repeat after an interval of at least 1 week for 3-5 courses.
Mycosis fungoides- 2.5-10 mg/day to induce remission.
Rheumatoid arthritis- 7.5 mg once weekly, adjust if needed. Up to 20 mg/wk.
Crohn's disease- 12.5-22.5 mg once weekly for up to 1 year.
PO/IV/IM- Psoriasis- 10-25 mg once wkly, adjust subsequent doses if needed.
IV- Osteosarcoma- 12-15 g/m2 as infusion, followed by folinic acid.
Breast cancer 10-60 mg/m2 often with cyclophosphamide and fluorouracil. Advanced lymphosarcoma Up to 30 mg/kg, followed by folinic acid rescue. Acute lymphoblastic leukaemia Maintenance: 2.5 mg/kg every 14 days.

How to use Neotrexate?

It comes as a tablet to take by mouth, with or without food.It also comes as a solution for injection to be administered by a healthcare provide into a large muscle.

When is Neotrexate not to be taken? (Contraindications)

It should not be administered during breast feeding. It should also not be used in patients allergic to the drug, pregnancy, liver disease, in alcoholics, people with low blood counts or decreased immunity.

Warnings and Precautions for Neotrexate

Caution should be exercised in patients with liver or kidney problems, blood disorders, diarrhea, and stomach problems.

• If vomiting or diarrhea occurs, you will need to take care not to become dehydrated.

• It may cause liver or kidney impairment, bone marrow depression, ulcerative disorders of the GI tract.

• Avoid become pregnant while taking this medication.

• Monitor hematological, renal and hepatic function and GI toxicity regularly.

• Avoid drinking alcohol while you are taking this medication.

Other Precautions for Neotrexate

Do not take medicines containing aspirin, ibuprofen or folic acid while taking this medication.

Storage Conditions for Neotrexate

Store intact vials at room temperature (15-25�C). Keep this medication in an airtight container.

Disclaimer : updates the prices regularly, however despite that there may be discrepancies in the prices displayed. This can be due to many reasons including -
  • Difference in GST/local taxes
  • Change in price by the company
  • Updation of information may not have happened at the right time
For the above reasons Medindia cannot be held liable for any action taken based on the information provided by its website. The purpose of this website is to only provide the initial guidance and it does not intend to replace professional medical opinion in any manner whatsoever.

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