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Rextop Gel (1% w/v) (1% w/v) is an antimetabolite, curative in choriocarcinoma (cancer of the tissue that normally would develop into placenta). It is also used in other cancers like blood, breast and lung cancers. It is also used to suppress immunity in conditions such as psoriasis and rheumatoid arthritis. 

Drug information on Rextop Gel (1% w/v) (1% w/v) (Methotrexate 1% w/v) from Systopic Laboratories Pvt. Ltd.

Rextop Gel (1% w/v) (1% w/v)

  Topical gel
Systopic Laboratories Pvt. Ltd.
Generic : Methotrexate
 109.00
1% w/v
10 g
Combination of Generics : Methotrexate 1% w/v
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Side effects of Methotrexate

  Central Nervous System: Dizziness, fatigue, headache, language disorder, weakness, paresis, convulsions, destruction of the myelin sheaths (IV after cranio spinal irradiation), inflammation of the arachnoid (a covering of the brain), transient paresis, nerve damage.

  Skin: Redness of the skin, rashes, itching, loss of hair, hives, photosensitivity, pigmentary changes, skin discoloration, dilatation of blood vessels, acne, furunculosis, aggravation of psoriasis by ultraviolet light, severe allergic reactions.

  Eye and ENT: Blurred vision, inflammation of the gums, inflammation of pharynx.

  Gastrointestinal: Nausea, vomiting, enteritis, mouth ulcer, diarrhea, abdominal distress (common), loss of appetite, blood in vomit, blood in stool, GI ulceration and bleeding.

  Genitourinary: Renal failure, blood contains excess amount nitrogen, inflammation of the urinary bladder, blood in urine, severe kidney disease, reproductive disorders, infertility, abortion, fetal defects.

  Blood: Deficiency of all three blood cell types, bone marrow depression, anemia, bleeding, presence of bacteria in the blood (septicemia).

  Liver: Elevated LFTs (liver function test), liver damage.

  Respiratory: Deaths from interstitial pneumonia, chronic interstitial obstructive lung disease.

  Miscellaneous: Malaise, chills, fever, lower resistance to infections, joint pain, muscle pain, diabetes, osteoporosis, allergic reactions, sudden death.

When is Methotrexate not to be taken? (Contraindications)

It should not be administered during breast feeding. It should also not be used in patients allergic to the drug, pregnancy, liver disease, in alcoholics, people with low blood counts or decreased immunity.


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