Drug information on Enerzal Liqd (Magnesium Sulphate) from FDC Limited (Proxima)

Medical Condition(s) for which Enerzal Liqd may be prescribed

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• Magnesium sulphate is important for muscles and nerves.
• It is also used as a laxative for constipation and to prevent and treat seizures in pre-eclampsia and eclampsia.

•  Digestive tract: Mild cramps, after constipation after taking laxative, diarrhea, stomach irritation, nausea, vomiting, paralytic ileus

•  Nervous system: Confusion, dizziness or lightheadedness, sleepiness, slurred speech, double vision, muscle weakness

•  Cardiovascular system: Fast, slow, or irregular heartbeat, low blood pressure

•  Skin: Skin infection after local application

•  Others: Allergic reaction

• The dosage and route of administration varies according to the condition for which magnesium sulphate is used, and the route of administration.

• The maintenance dose should be adjusted according to the response noted.

• Depending on the dosage form, magnesium sulphate is taken orally, injected into the muscle or a vein, or applied on the skin.

Magnesium sulphate is contraindicated in patients with:

• Allergy to the drug
• Kidney disease
• Heart disease like heart block or heart muscle damage, or patients on digoxin treatment
• Myasthenia gravis
• Severe nausea, vomiting, perforation of bowel, bowel obstruction, sudden changes in bowel habits (for magnesium sulphate laxative)

• Monitor kidney function, blood pressure and respiratory rate regularly during treatment with magnesium sulphate.
• Oral magnesium sulphate should not be used in pregnancy.

• Take magnesium sulphate only as advised by the physician.

• Magnesium sulphate when it is combined with drugs that include tetracycline antibiotics like demeclocycline, doxycycline and minocycline, and biphosphonates decreases their absorption from the digestive tract.
• Magnesium sulphate causes additional neuromuscular blocking effect with drugs like aminoglycosides, and nifedipine and nimodipine.

• Magnesium sulphate may increase drowsiness caused by other drugs with sedative effects.
• It should not be used in patients taking digoxin for heart disease.

• Magnesium sulphate should be stored at room temperature of 20°C to 25°C.