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Drug information on Durea (Hydroxyurea) from Samarth Pharma Pvt. Ltd.

Durea   Capsule/ Tablet Samarth Pharma Pvt. Ltd. Generic : Hydroxyurea	307.20 500mg 4 x 6

Acute Lymphoblastic Leukemia

Acute Myeloid Leukemia

AIDS/HIV

Chemotherapy

Chronic Lymphocytic Leukemia

Chronic Myeloid Leukemia

Hodgkins Lymphoma

Non-Hodgkins Lymphoma

•   Most common : Bone marrow depression.

•   Gastrointestinal : Mouth ulcer, loss of appetite, nausea, vomiting, diarrhea and constipation.

•   Skin : Rash, skin ulceration, skin changes and redness.

Intermittent Therapy
80 mg/kg administered orally as a single dose every third day.
Continuous Therapy
20 to 30 mg/kg administered orally as a single dose daily.
Concomitant Therapy with Irradiation
Carcinoma of the head and neck—80 mg/kg administered orally as a single dose every third day.

It comes as a capsule and tablet to take by mouth, with or without food.

Contraindicated in patients with severe bone marrow depression, abnormal decrease in blood cell counts and hypersensitivity.

• Caution should be exercised in patients with history of AIDS, who have undergone radiation therapy, liver or kidney disease, any allergy, who are taking other medications, during pregnancy and breastfeeding.

• It may reduce platelet counts; avoid injury or bruising.

• It may be harmful if it gets on the skin; avoid direct contact with hands.

• Avoid vaccination while taking this medication.

Avoid drinking alcoholic beverages and citrus juices.
Avoid excess dosage.

Keep it out of reach of children in a safe place.