A: Pioryl 2 is safe, effective in diabetic patients with renal impairment. Patients with mild to severe kidney disease can take Pioryl 2, but they should start slowly and gradually increase the dose (3✔✔Trusted Source Pharmacokinetics and safety of glimepiride at clinically effective doses in diabetic patients with renal impairment
A: Pioryl 2 may cause weight gain. Sulfonylureas drugs commonly used to treat diabetes are associated with weight gain. Pioryl 2 should be used in combination with a healthy diet and regular exercise to help control weight gain (2✔✔Trusted Source Glimepiride
3. Pharmacokinetics and safety of glimepiride at clinically effective doses in diabetic patients with renal impairment - (https://pubmed.ncbi.nlm.nih.gov/8960852/#:)
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