Gliclazide (Mefinda GCL) is an oral hypoglycemic (anti-diabetic drug), prescribed for type 2 diabetes. It stimulates the pancreas, which helps in more insulin secretion.
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Q: What happens if Mefinda GCL is taken on an empty stomach?
A: Mefinda GCL should be taken 30 minutes before breakfast. Mefinda GCL promotes more appropriate insulin release and better glucose disposition when taken 30 minutes before breakfast than when taken with breakfast(1✔✔Trusted Source Influence of food intake on the absorption and effect of glipizide in diabetics and in healthy subjects
A: Sulfonylureas have been linked to an increased risk of drug-induced idiosyncratic liver disease. A diabetic patient developed acute icteric liver necro-inflammation after starting Mefinda GCL therapy(2✔✔Trusted Source Gliclazide-induced acute hepatitis
A: Mefinda GCL not only has a hypoglycemic action but also possesses antiplatelet activity by inhibiting platelet aggregation via the serotonin pathway(3✔✔Trusted Source Effects of gliclazide on platelet aggregation and the plasminogen activator inhibitor type 1 level in patients with type 2 diabetes mellitus
A: The use of oral diabetes medications during pregnancy is not advised due to known adverse effects on the fetus, such as congenital abnormalities, fetal hyperinsulinemia, and neonatal hypoglycemia(4✔✔Trusted Source Normal pregnancy and healthy child after continued exposure to gliclazide and ramipril during pregnancy
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1. Influence of food intake on the absorption and effect of glipizide in diabetics and in healthy subjects - (https://pubmed.ncbi.nlm.nih.gov/7002565/)
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