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Glisafe - M (Gliclazide) Drug Price and Information

Gliclazide (Glisafe - M) is an oral hypoglycemic (anti-diabetic drug), prescribed for type 2 diabetes. It stimulates the pancreas, which helps in more insulin secretion.

Glisafe - M - Indus Drugs

Glisafe - M  Tablet  


Generic : Gliclazide
 32.00
80mg/500mg
10 Tablets
Price Updated on August 8, 2019
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Drug information on Glisafe - M (Gliclazide) from Indus Drugs

Written & Compiled by Anushta Chandrapalan, M.Sc  | Medically Reviewed by The Medindia Medical Review Team
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Medical condition(s) for which Glisafe - M may be prescribed

Dosage & When it is to be taken (Indications)

PO- Initially start with 160mgs daily in two divided doses. May go up to 320 mgs daily in two divided doses.

Side effects of Glisafe - M

GI disturbances, skin reaction, decrease in blood cell counts, jaundice, vomiting, diarrhea and stomach inflammation.

How to use Glisafe - M?

It comes as a tablet to take by mouth, with food.

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When Should Glisafe - M not be taken? (Contraindications)

Contraindicated in patients with diabetic-ketoacidosis, severe liver and kidney impairment, and hypersensitivity.

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Warnings and Precautions for Glisafe - M

Caution should be exercised in patients with history of liver, kidney problems, any allergy, during pregnancy and breastfeeding.

Monitor bloodsugar level regularly while taking this medication.

Other Precautions for Glisafe - M

Avoid excess dosage.

Storage Conditions for Glisafe - M

Store it at room temperature.


Schedule : H  Prescription drugs - Drugs to be sold only under the prescription of a Registered Medical Practitioner.



Glisafe - M(Gliclazide) : Frequently Asked Questions

Q: What happens if Glisafe - M is taken on an empty stomach?

A: Glisafe - M should be taken 30 minutes before breakfast. Glisafe - M promotes more appropriate insulin release and better glucose disposition when taken 30 minutes before breakfast than when taken with breakfast(1 Trusted Source
Influence of food intake on the absorption and effect of glipizide in diabetics and in healthy subjects

Go to source
).

Q: Does Glisafe - M affect liver?

A:  Sulfonylureas have been linked to an increased risk of drug-induced idiosyncratic liver disease. A diabetic patient developed acute icteric liver necro-inflammation after starting Glisafe - M therapy(2 Trusted Source
Gliclazide-induced acute hepatitis

Go to source
).

Q: Does Glisafe - M have antiplatelet activity?

A: Glisafe - M not only has a hypoglycemic action but also possesses antiplatelet activity by inhibiting platelet aggregation via the serotonin pathway(3 Trusted Source
Effects of gliclazide on platelet aggregation and the plasminogen activator inhibitor type 1 level in patients with type 2 diabetes mellitus

Go to source
).

Q: Is Glisafe - M contraindicated in pregnancy?

A: The use of oral diabetes medications during pregnancy is not advised due to known adverse effects on the fetus, such as congenital abnormalities, fetal hyperinsulinemia, and neonatal hypoglycemia(4 Trusted Source
Normal pregnancy and healthy child after continued exposure to gliclazide and ramipril during pregnancy

Go to source
).

Q: Is Glipizide same as Glisafe - M?

A: Glipizide and Glisafe - M are not the same medication. Glisafe - M and glipizide belong to the same sulfonylurea class(5 Trusted Source
Sulfonylureas

Go to source
).

  • 1. Influence of food intake on the absorption and effect of glipizide in diabetics and in healthy subjects - (https://pubmed.ncbi.nlm.nih.gov/7002565/)
  • 2. Gliclazide-induced acute hepatitis - (https://pubmed.ncbi.nlm.nih.gov/10656221/#:)
  • 3. Effects of gliclazide on platelet aggregation and the plasminogen activator inhibitor type 1 level in patients with type 2 diabetes mellitus - (https://pubmed.ncbi.nlm.nih.gov/20070990/#:)
  • 4. Normal pregnancy and healthy child after continued exposure to gliclazide and ramipril during pregnancy - (https://pubmed.ncbi.nlm.nih.gov/19109210/)
  • 5. Sulfonylureas - (https://www.ncbi.nlm.nih.gov/books/NBK513225/)
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