Q: What happens if Bezide (80+500) is taken on an empty stomach?
A: Bezide (80+500) should be taken 30 minutes before breakfast. Bezide (80+500) promotes more appropriate insulin release and better glucose disposition when taken 30 minutes before breakfast than when taken with breakfast(1✔✔Trusted Source Influence of food intake on the absorption and effect of glipizide in diabetics and in healthy subjects
A: Sulfonylureas have been linked to an increased risk of drug-induced idiosyncratic liver disease. A diabetic patient developed acute icteric liver necro-inflammation after starting Bezide (80+500) therapy(2✔✔Trusted Source Gliclazide-induced acute hepatitis
Q: Does Bezide (80+500) have antiplatelet activity?
A: Bezide (80+500) not only has a hypoglycemic action but also possesses antiplatelet activity by inhibiting platelet aggregation via the serotonin pathway(3✔✔Trusted Source Effects of gliclazide on platelet aggregation and the plasminogen activator inhibitor type 1 level in patients with type 2 diabetes mellitus
Q: Is Bezide (80+500) contraindicated in pregnancy?
A: The use of oral diabetes medications during pregnancy is not advised due to known adverse effects on the fetus, such as congenital abnormalities, fetal hyperinsulinemia, and neonatal hypoglycemia(4✔✔Trusted Source Normal pregnancy and healthy child after continued exposure to gliclazide and ramipril during pregnancy
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