Glibenclamide (Dutrol) is an oral hypoglycemic (glucose lowering) drug used to control blood sugar levels in patients with type 2 diabetes in addition to diet and exercise. It belongs to the chemical group of sulfonylureas.
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Others: Tiredness, weakness, fever, other allergic reactions, weight gain, joint or muscle pain, vasculitis.
How to use Dutrol?
• This drug should be taken orally once daily after breakfast or after the first meal of the day.
In which conditions should Dutrol be avoided?
Glibenclamide should not be used in patients with:
• Allergy to the drug • Diabetic ketoacidosis, which requires insulin treatment • Type 1 diabetes, where it is ineffective • Glucose-6-phosphate dehydrogenase deficiency, due to the risk of breakdown of red blood cells (hemolytic anemia) • Severe liver or kidney disease
It should also be avoided in: • Pregnancy and breastfeeding • Patients taking bosentan, due to a risk of liver damage
What are the Precautions needed with Dutrol
• Monitor blood sugar level on a regular basis during the treatment
• Patients undergoing stressful conditions like fever, trauma or surgery may require temporary switching to insulin
• Use with caution in patients with diabetes-related nerved damage or with endocrine disorders
• Patients should be taught to recognize symptoms of low blood sugar and how to treat it on an emergency basis.
• They should be advised to contact an emergency center at the earliest.
Are there any additional Precautions?
• Alcohol intake should be stopped while taking this drug since the combination can result in an unpleasant reaction called disulfiram-type reaction. • Also, alcohol can also cause additional reduction in blood glucose levels.
Drug Interactions of Dutrol
• Glibenclamide can interact with the following medications when taken together:
• Drugs like non-steroidal painkillers, ciprofloxacin and propranolol can increase the chances of lowering the blood sugar levels below normal and resulting in hypoglycemia. • Bosentan can increase the risk of liver damage. • Thiazide diuretics, corticosteroids, and other drugs could increase blood sugar levels and result in loss of blood glucose control. • Colesevelam, can reduce glibenclamide levels in the blood. Therefore, glibenclamide should be taken at least 4 hours before colesevelam.
At What Temperature Should it be Stored?
• Should be stored at room temperature, keep it away from heat.
A: Dutrol is not advised for the treatment of gestational diabetes. Dutrol is not recommended for use in pregnancy when insulin and metformin are available(3✔✔Trusted Source Glyburide and fetal safety; transplacental pharmacokinetic considerations
A: Dutrol is not recommended for patients with stage 3 chronic kidney disease. Patients with moderate CKD who are treated with Dutrol require careful monitoring due to increased risk of hypoglycemia(4✔✔Trusted Source Diabetes treatment in patients with renal disease: Is the landscape clear enough?
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3. Glyburide and fetal safety; transplacental pharmacokinetic considerations - (https://pubmed.ncbi.nlm.nih.gov/11390165/)
4. Diabetes treatment in patients with renal disease: Is the landscape clear enough? - (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138588/#)
5. Weight Considerations in Pharmacotherapy for Type 2 Diabetes - (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946585/)
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