Duotrol SR (2.5+500) (Glibenclamide) Drug Price and Information
Glibenclamide (Duotrol SR (2.5+500)) is an oral hypoglycemic (glucose lowering) drug used to control blood sugar levels in patients with type 2 diabetes in addition to diet and exercise. It belongs to the chemical group of sulfonylureas.
Others: Tiredness, weakness, fever, other allergic reactions, weight gain, joint or muscle pain, vasculitis.
How to use Duotrol SR (2.5+500)?
• This drug should be taken orally once daily after breakfast or after the first meal of the day.
When Should Duotrol SR (2.5+500) not be taken? (Contraindications)
Glibenclamide should not be used in patients with:
• Allergy to the drug • Diabetic ketoacidosis, which requires insulin treatment • Type 1 diabetes, where it is ineffective • Glucose-6-phosphate dehydrogenase deficiency, due to the risk of breakdown of red blood cells (hemolytic anemia) • Severe liver or kidney disease
It should also be avoided in: • Pregnancy and breastfeeding • Patients taking bosentan, due to a risk of liver damage
Warnings and Precautions for Duotrol SR (2.5+500)
• Monitor blood sugar level on a regular basis during the treatment
• Patients undergoing stressful conditions like fever, trauma or surgery may require temporary switching to insulin
• Use with caution in patients with diabetes-related nerved damage or with endocrine disorders
• Patients should be taught to recognize symptoms of low blood sugar and how to treat it on an emergency basis.
• They should be advised to contact an emergency center at the earliest.
Other Precautions for Duotrol SR (2.5+500)
• Alcohol intake should be stopped while taking this drug since the combination can result in an unpleasant reaction called disulfiram-type reaction. • Also, alcohol can also cause additional reduction in blood glucose levels.
Drug Interactions of Duotrol SR (2.5+500)
• Glibenclamide can interact with the following medications when taken together:
• Drugs like non-steroidal painkillers, ciprofloxacin and propranolol can increase the chances of lowering the blood sugar levels below normal and resulting in hypoglycemia. • Bosentan can increase the risk of liver damage. • Thiazide diuretics, corticosteroids, and other drugs could increase blood sugar levels and result in loss of blood glucose control. • Colesevelam, can reduce glibenclamide levels in the blood. Therefore, glibenclamide should be taken at least 4 hours before colesevelam.
Storage Conditions for Duotrol SR (2.5+500)
• Should be stored at room temperature, keep it away from heat.
Duotrol SR (2.5+500)(Glibenclamide) : Frequently Asked Questions
Q: When is the best time to take Duotrol SR (2.5+500)?
A: Duotrol SR (2.5+500) is usually taken once a day with breakfast. Take Duotrol SR (2.5+500) around the same time every day(1✔✔Trusted Source Glyburide
A: Duotrol SR (2.5+500) is not advised for the treatment of gestational diabetes. Duotrol SR (2.5+500) is not recommended for use in pregnancy when insulin and metformin are available(3✔✔Trusted Source Glyburide and fetal safety; transplacental pharmacokinetic considerations
Q: Is Duotrol SR (2.5+500) safe in kidney failure?
A: Duotrol SR (2.5+500) is not recommended for patients with stage 3 chronic kidney disease. Patients with moderate CKD who are treated with Duotrol SR (2.5+500) require careful monitoring due to increased risk of hypoglycemia(4✔✔Trusted Source Diabetes treatment in patients with renal disease: Is the landscape clear enough?
A: Duotrol SR (2.5+500) may cause weight gain. Sulfonylureas drugs commonly used to treat diabetes are associated with weight gain(5✔✔Trusted Source Weight Considerations in Pharmacotherapy for Type 2 Diabetes
3. Glyburide and fetal safety; transplacental pharmacokinetic considerations - (https://pubmed.ncbi.nlm.nih.gov/11390165/)
4. Diabetes treatment in patients with renal disease: Is the landscape clear enough? - (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138588/#)
5. Weight Considerations in Pharmacotherapy for Type 2 Diabetes - (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946585/)
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