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Diabetrol (5+500) (Glibenclamide) Drug Price and Information

Glibenclamide (Diabetrol (5+500)) is an oral hypoglycemic (glucose lowering) drug used to control blood sugar levels in patients with type 2 diabetes in addition to diet and exercise.
It belongs to the chemical group of sulfonylureas.  

Diabetrol (5+500) - Abbott Healthcare Pvt Ltd (AHPL)

Diabetrol (5+500)  Tablet  

Generic : Glibenclamide
10 Tablets
Price Updated on August 8, 2019
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Drug information on Diabetrol (5+500) (Glibenclamide) from Abbott Healthcare Pvt Ltd (AHPL)


Medical condition(s) for which Diabetrol (5+500) may be prescribed

Overview of Diabetrol (5+500)

• Glibenclamide (glyburide) is an oral anti-diabetic drug.
• It is used for the treatment of type 2 diabetes to control the blood sugar level.


Dosage & When it is to be taken (Indications)

• The treatment is started with a low dose of 2.5 mg per day, and increased up to a maximum of 20 mg per day according to the blood glucose levels.

Side effects of Diabetrol (5+500)

Digestive tract: Nausea, vomiting, flatulence, abdominal fullness, diarrhea, constipation, heartburn, liver dysfunction

Skin: Rash, skin swelling, photosensitivity reactions (skin reactions following exposure to sunlight) including porphyria cutanea tarda (which is associated with an enzyme deficiency)

Blood: Low blood counts, low blood glucose levels, low blood sodium levels

Others: Tiredness, weakness, fever, other allergic reactions, weight gain, joint or muscle pain, vasculitis.

How to use Diabetrol (5+500)?

• This drug should be taken orally once daily after breakfast or after the first meal of the day.


When Should Diabetrol (5+500) not be taken? (Contraindications)

Glibenclamide should not be used in patients with:

• Allergy to the drug
Diabetic ketoacidosis, which requires insulin treatment
• Type 1 diabetes, where it is ineffective
• Glucose-6-phosphate dehydrogenase deficiency, due to the risk of breakdown of red blood cells (hemolytic anemia)
• Severe liver or kidney disease

It should also be avoided in:
• Pregnancy and breastfeeding
• Patients taking bosentan, due to a risk of liver damage

Warnings and Precautions for Diabetrol (5+500)

• Monitor blood sugar level on a regular basis during the treatment

• Patients undergoing stressful conditions like fever, trauma or surgery may require temporary switching to insulin

• Use with caution in patients with diabetes-related nerved damage or with endocrine disorders

• Patients should be taught to recognize symptoms of low blood sugar and how to treat it on an emergency basis.

• They should be advised to contact an emergency center at the earliest.

Other Precautions for Diabetrol (5+500)

• Alcohol intake should be stopped while taking this drug since the combination can result in an unpleasant reaction called disulfiram-type reaction.
• Also, alcohol can also cause additional reduction in blood glucose levels.

Drug Interactions of Diabetrol (5+500)

• Glibenclamide can interact with the following medications when taken together:

• Drugs like non-steroidal painkillers, ciprofloxacin and propranolol can increase the chances of lowering the blood sugar levels below normal and resulting in hypoglycemia.
• Bosentan can increase the risk of liver damage.
• Thiazide diuretics, corticosteroids, and other drugs could increase blood sugar levels and result in loss of blood glucose control.
• Colesevelam, can reduce glibenclamide levels in the blood. Therefore, glibenclamide should be taken at least 4 hours before colesevelam.

Storage Conditions for Diabetrol (5+500)

• Should be stored at room temperature, keep it away from heat.

Diabetrol (5+500)(Glibenclamide) : Frequently Asked Questions

Q: When is the best time to take Diabetrol (5+500)?

A: Diabetrol (5+500) is usually taken once a day with breakfast. Take Diabetrol (5+500) around the same time every day(1 Trusted Source

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Q: Is Diabetrol (5+500) same as glyburide?

A: Diabetrol (5+500) belongs to the class of sulfonylurea oral hypoglycemic agents. Diabetrol (5+500) is also known as glyburide(2 Trusted Source

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Q: Is Diabetrol (5+500) safe in pregnancy?

A: Diabetrol (5+500) is not advised for the treatment of gestational diabetes. Diabetrol (5+500) is not recommended for use in pregnancy when insulin and metformin are available(3 Trusted Source
Glyburide and fetal safety; transplacental pharmacokinetic considerations

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Q: Is Diabetrol (5+500) safe in kidney failure?

A: Diabetrol (5+500) is not recommended for patients with stage 3 chronic kidney disease. Patients with moderate CKD who are treated with Diabetrol (5+500) require careful monitoring due to increased risk of hypoglycemia(4 Trusted Source
Diabetes treatment in patients with renal disease: Is the landscape clear enough?

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Q: Does Diabetrol (5+500) cause weight gain?

A: Diabetrol (5+500) may cause weight gain. Sulfonylureas drugs commonly used to treat diabetes are associated with weight gain(5 Trusted Source
Weight Considerations in Pharmacotherapy for Type 2 Diabetes

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  • 1. Glyburide - (https://medlineplus.gov/druginfo/meds/a684058.html)
  • 2. Glibenclamide - (https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/glibenclamide)
  • 3. Glyburide and fetal safety; transplacental pharmacokinetic considerations - (https://pubmed.ncbi.nlm.nih.gov/11390165/)
  • 4. Diabetes treatment in patients with renal disease: Is the landscape clear enough? - (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138588/#)
  • 5. Weight Considerations in Pharmacotherapy for Type 2 Diabetes - (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946585/)
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