Name: Combidos
Creator: Pallavi Singh

Glibenclamide is an oral hypoglycemic (glucose lowering) drug used to control blood sugar levels in patients with type 2 diabetes in addition to diet and exercise.
It belongs to the chemical group of sulfonylureas.

Combidos Tablet Medopharm Generic : Glibenclamide	₹ 12.00 500mg/5mg 10 Tablets

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Drug information on Combidos (Glibenclamide) from Medopharm

Drug Name : Glibenclamide

Glibenclamide generic Glibenclamide is an oral hypoglycemic (glucose lowering) drug used to control blood sugar levels in patients with type 2 diabetes in addition to diet and exercise. It belongs to the chemical group of sulfonylureas.
More Info about Glibenclamide

Written & Compiled by Pharmacist Pallavi Singh, M. Pharmacy (Pharmacy Practice)

Medically Reviewed by Dr. Simi Paknikar, MD

Last Updated on February, 2, 2017

Medical condition(s) for which Combidos may be prescribed

Diabetes

Non-Communicable Diseases

Polyuria

Study of Continuous Glucose Monitoring

Type 2 Diabetes

Ways to Prevent Blood Sugar Spikes After Meals

Overview of Combidos

• Glibenclamide (glyburide) is an oral anti-diabetic drug.
• It is used for the treatment of type 2 diabetes to control the blood sugar level.

Dosage & When it is to be taken (Indications)

• The treatment is started with a low dose of 2.5 mg per day, and increased up to a maximum of 20 mg per day according to the blood glucose levels.

Side effects of Combidos

Digestive tract: Nausea, vomiting, flatulence, abdominal fullness, diarrhea, constipation, heartburn, liver dysfunction

Skin: Rash, skin swelling, photosensitivity reactions (skin reactions following exposure to sunlight) including porphyria cutanea tarda (which is associated with an enzyme deficiency)

Blood: Low blood counts, low blood glucose levels, low blood sodium levels

Others: Tiredness, weakness, fever, other allergic reactions, weight gain, joint or muscle pain, vasculitis.

How to use Combidos?

• This drug should be taken orally once daily after breakfast or after the first meal of the day.

When Should Combidos not be taken? (Contraindications)

Glibenclamide should not be used in patients with:

• Allergy to the drug
• Diabetic ketoacidosis, which requires insulin treatment
• Type 1 diabetes, where it is ineffective
• Glucose-6-phosphate dehydrogenase deficiency, due to the risk of breakdown of red blood cells (hemolytic anemia)
• Severe liver or kidney disease

It should also be avoided in:
• Pregnancy and breastfeeding
• Patients taking bosentan, due to a risk of liver damage

Warnings and Precautions for Combidos

• Monitor blood sugar level on a regular basis during the treatment

• Patients undergoing stressful conditions like fever, trauma or surgery may require temporary switching to insulin

• Use with caution in patients with diabetes-related nerved damage or with endocrine disorders

• Patients should be taught to recognize symptoms of low blood sugar and how to treat it on an emergency basis.

• They should be advised to contact an emergency center at the earliest.

Other Precautions for Combidos

• Alcohol intake should be stopped while taking this drug since the combination can result in an unpleasant reaction called disulfiram-type reaction.
• Also, alcohol can also cause additional reduction in blood glucose levels.

Drug Interactions of Combidos

• Glibenclamide can interact with the following medications when taken together:

• Drugs like non-steroidal painkillers, ciprofloxacin and propranolol can increase the chances of lowering the blood sugar levels below normal and resulting in hypoglycemia.
• Bosentan can increase the risk of liver damage.
• Thiazide diuretics, corticosteroids, and other drugs could increase blood sugar levels and result in loss of blood glucose control.
• Colesevelam, can reduce glibenclamide levels in the blood. Therefore, glibenclamide should be taken at least 4 hours before colesevelam.

Storage Conditions for Combidos

• Should be stored at room temperature, keep it away from heat.

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