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Drug information on Combidos (Glibenclamide) from Medopharm

Combidos   Tablet   Medopharm Generic : Glibenclamide	12.00 500mg/5mg 10 Tablets

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Written & Compiled by Pharmacist Pallavi Singh, M. Pharmacy (Pharmacy Practice)

Medically Reviewed by Dr. Simi Paknikar, MD

Last Updated on Mar 29, 2018

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Diabetes

Polyuria

Type 2 Diabetes

• Glibenclamide (glyburide) is an oral anti-diabetic drug.
• It is used for the treatment of type 2 diabetes to control the blood sugar level.

•  Digestive tract: Nausea, vomiting, flatulence, abdominal fullness, diarrhea, constipation, heartburn, liver dysfunction

•  Skin: Rash, skin swelling, photosensitivity reactions (skin reactions following exposure to sunlight) including porphyria cutanea tarda (which is associated with an enzyme deficiency)

•  Blood: Low blood counts, low blood glucose levels, low blood sodium levels

•  Others: Tiredness, weakness, fever, other allergic reactions, weight gain, joint or muscle pain, vasculitis.

• The treatment is started with a low dose of 2.5 mg per day, and increased up to a maximum of 20 mg per day according to the blood glucose levels.

• This drug should be taken orally once daily after breakfast or after the first meal of the day.

Glibenclamide should not be used in patients with:

• Allergy to the drug
• Diabetic ketoacidosis, which requires insulin treatment
• Type 1 diabetes, where it is ineffective
• Glucose-6-phosphate dehydrogenase deficiency, due to the risk of breakdown of red blood cells (hemolytic anemia)
• Severe liver or kidney disease

It should also be avoided in:
• Pregnancy and breastfeeding
• Patients taking bosentan, due to a risk of liver damage

• Monitor blood sugar level on a regular basis during the treatment
• Patients undergoing stressful conditions like fever, trauma or surgery may require temporary switching to insulin
• Use with caution in patients with diabetes-related nerved damage or with endocrine disorders
• Patients should be taught to recognize symptoms of low blood sugar and how to treat it on an emergency basis.
• They should be advised to contact an emergency center at the earliest.

• Alcohol intake should be stopped while taking this drug since the combination can result in an unpleasant reaction called disulfiram-type reaction.
• Also, alcohol can also cause additional reduction in blood glucose levels.

• Glibenclamide can interact with the following medications when taken together:

• Drugs like non-steroidal painkillers, ciprofloxacin and propranolol can increase the chances of lowering the blood sugar levels below normal and resulting in hypoglycemia.
• Bosentan can increase the risk of liver damage.
• Thiazide diuretics, corticosteroids, and other drugs could increase blood sugar levels and result in loss of blood glucose control.
• Colesevelam, can reduce glibenclamide levels in the blood. Therefore, glibenclamide should be taken at least 4 hours before colesevelam.

• Should be stored at room temperature, keep it away from heat.