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Drug information on Abigest N (100 mg) (Dydrogesterone) from Alpic Biotech Ltd.

Abigest N (100 mg)   Capsule Alpic Biotech Ltd. Generic : Dydrogesterone	99.50 100mg 10 Capsules

Information Checked by Dhanalakshmi Chinnuswamy, Diploma in Pharmacy, MBA (Healthcare)

Further Checked by The Medindia Medical Review Team on February, 2, 2017

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Miscarriage

Premenstrual Syndrome

Dydrogesterone is a synthetic progesterone. Progesterone is a female hormone which is responsible for the healthy growth of the womb (uterine) lining also known as endometrial. If the egg released during the menstrual cycle is not fertilized, progesterone levels decrease and initiates proper shedding of the womb lining (menstruation). If the egg is fertilized and attaches to the womb lining, progesterone levels continue to increase and helps in maintaining the integrity of womb lining which is very necessary to preserve the pregnancy.
Dydrogesterone is used to mimic the action of progesterone in various conditions

• Pulsating headache which can develop into a migraine
• Pain in breast and breast tenderness
• Occasional blood spotting
• Pain during periods
• Irregular period
• Heavy bleeding during periods
• Missed period
• Weight gain
• Depression
• Abnormal liver function which can progress into jaundice Nausea and abdominal discomfort
• Hypersensitivity

Drug dosage varies as per the medical condition.

• Painful menstruation and irregular menstrual periods: 10 mg twice daily from starting from the 5th day of the menstrual cycle to the 25th day.
• Endometriosis: 10 mg twice or thrice daily starting from the 5th day of the menstrual cycle to the 25th day.
• Dysfunctional bleeding/ unexpected bleeding:
• 10 mg twice daily for a week for stopping bleeding.
• 10 mg twice daily starting from the 11th day of the menstrual cycle to 25th day to prevent heavy bleeding.
• Secondary Amenorrhea: Should be given in combination with estrogen therapy. 10 mg twice daily starting from the 11th day of the menstrual cycle to the 25th day.
• Abortion: In case of threatened abortion, 40 mg immediately and then 10 mg doses repeated every 8 hours till remission.
• In case of habitual abortion, 10 mg once daily till 12th week of pregnancy.
• Infertility: 10 mg once daily from 14th day of menstrual cycle to 25th day.
• In post-menopausal conditions: Should be given in combination with estrogen therapy in a dose of 2.5 mg to 10 mg once daily as per the severity of the condition.

It comes as a tablet to take by mouth, with or without food.

Contraindicated in patients with undiagnosed, abnormal vaginal bleeding, blood clot disorder, stroke, incomplete abortion, breast cancer, brain cancer, breastfeeding mothers, liver dysfunction, and hypersensitivity.
The drug is contraindicated in children under age 18 years.
While the drug is useful in sustaining pregnancy in patients with recurrent abortion, the drug is contraindicated in pregnant patients who are not at any risk of abortion or in patients with advanced pregnancy.

• Patients should be monitored for visual disturbances, migraine headache or embolic disorders.
• The duration and the frequency of the treatment should be decided by the treating physician.
• If any allergic reaction reactions occur, the medicine has to be stopped and should consult a physician.

Caution should be exercised in patients with a history of blood clot disorder, kidney impairment, heart disease, epilepsy, asthma, migraine, fluid retention, and breastfeeding. Monitor closely eye vision and symptoms of blood clot disorders.
It may cause dizziness, do not drive a car or operate machinery while taking this medication.
Should be used with extreme care in patient with a history of clinical depression.

No specific symptoms are observed with drug overdose. Treatment is symptomatic and supportive.

Store in a dry, dark place at temperatures not exceeding 25°C. Keep out of reach of children.