Donepezil (Donecept) is a cholinesterase inhibitor, prescribed for dementia of Alzheimer's disease. It works by increasing the amount of acetylcholine in the brain, which helps in improving mental function.
Adult: PO- Initial: 5 mg/day in the evening, up to 10 mg/day after 4-6 week.
Side effects of Donecept
Most frequent : Nausea, diarrhea, vomiting, muscle cramps, fatigue and loss of appetite.
Body as a Whole : Headache, generalized pain and fatigue.
Heart : Fainting.
Blood : Bruising.
Metabolic : Decreased weight.
Musculoskeletal : Muscle cramps and joint inflammation.
Central Nervous System : Sleeplessness, dizziness, depression, abnormal dreams and drowsiness.
Genitourinary : Frequent urination.
How to use Donecept?
It comes as a tablet to take by mouth, with or without food.
When Should Donecept not be taken? (Contraindications)
Warnings and Precautions for Donecept
Caution should be exercised in patients with history of heart disease, stomach problems, liver or kidney disease, breathing problems, urinary obstruction, brain tumor, head injury, seizures, any allergy, who are taking other medications, during pregnancy and breastfeeding.
It may cause drowsiness, dizziness, or fainting, do not drive a car or operate machinery while taking this medication.
It should not be used in children.
Other Precautions for Donecept
Avoid excess dosage.
Storage Conditions for Donecept
Store it at controlled room temperature (15° to 30°C), and in an airtight container.
Donecept(Donepezil) : Frequently Asked Questions
Q: When is the best time to take Donecept?
A: Donecept is usually taken once daily, with or without food, in the evening before going to bed. Donecept should be taken every day at the same time(1✔✔Trusted Source Donepezil
A: The most common adverse effects of Donecept are the gastrointestinal side effects that can cause loss of appetite and weight loss. It can cause weight loss in 5% of patients. The incidence rises with increasing doses(2✔✔Trusted Source Rivastigmine Improves Appetite by Increasing the Plasma Acyl/Des-Acyl Ghrelin Ratio and Cortisol in Alzheimer Disease
A: Donecept may cause an increase in gastric acid secretion. Donecept should be used with caution in patients at risk of developing ulcer disease, and GI bleeding symptoms must be monitored(3✔✔Trusted Source Donepezil
Q: What happens if Donecept is taken more than the recommended dose?
A: Donecept overdose can cause severe nausea, vomiting, sweating, and salivation. Bradycardia, hypotension, respiratory depression, collapse, muscle weakness, and seizures are all possible side effects(3✔✔Trusted Source Donepezil
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