Valparin Chrono 500 is an anticonvulsant, prescribed for bipolar disorder, epilepsy and to prevent migraine headache. It controls the abnormal activity of nerve impulses in the brain and central nervous system.

Drug information on Valparin Chrono 500 (Divalproex) from Sanofi Aventis Pharma India

Valparin Chrono 500

Sanofi Aventis Pharma India
Generic : Divalproex
10 Tablets
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Medical Condition(s) for which Valparin Chrono 500 may be prescribed

Tuberous Sclerosis

Side effects of Valparin Chrono 500

  Most Common: Nausea, vomiting, drowsiness, dizziness, weakness, abdominal pain, indigestion and rash.

  Body as a Whole: Chest pain, chills, fever, neck pain and neck rigidity.

  Heart: High/low blood pressure, fast heart rate and dilation of blood vessels.

  Gastrointestinal: Loss of appetite, fecal incontinence, flatulence, inflammation of gastrointestinal tract/tongue and mouth infection.

  Blood: Bruising.

  Metabolic : Swelling in the extremities and weight gain.

  Musculoskeletal: Joint pain, leg cramps and twitching.

  Central Nervous System: Abnormal dreams, abnormal gait, agitation, in-coordination, muscle rigidity, memory loss, sleeplessness, tingling, involuntary movements, abnormal thinking and fainting.

  Respiratory : Difficulty in breathing and inflammation of nose.

  Skin : Hair loss, skin scar, dry skin, boils, rash, itching and dandruff.

  Eye and ENT: Lazy eye, inflammation of eyes, dry eyes, double vision, deafness, ear/eye pain and ringing in the ear.

  Genitourinary: Painful menstrual period/urination, urinary incontinence and vaginal inflammation.

Dosage & When it is to be taken (Indications)

Adult: PO- Partial seizures; Primary generalized seizures- Initial-10-15 mg/kg/day in 2-4 divided doses. Max: 60 mg/kg/day.
Acute manic episodes of bipolar disorder- Initial- 25 mg/kg once daily. Max: 60 mg/kg/day.
Migraine prophylaxis- 500 mg once daily for 1 wk, up to 1,000 mg once daily.

How to use Valparin Chrono 500?

It comes as a tablet to take by mouth, with food.

When is Valparin Chrono 500 not to be taken? (Contraindications)

Contraindicated in patients with known hypersensitivity and urea cycle disorder.

Warnings and Precautions for Valparin Chrono 500

Caution should be exercised in patients with history of brain, liver, kidney problems, metabolic disease, blood disease, decrease in albumin, HIV infection, elderly, children, during pregnancy and breastfeeding.

• It may cause dizziness, drowsiness, or blurred vision, do not drive a car or operate machinery and get up slowly from bed while taking this medication.

• Avoid alcohol consumption.

• Patient may develop with an increased risk of pancreatic inflammation and suicidal thoughts, if it so consult with your doctor.

Other Precautions for Valparin Chrono 500

It may lead to poor blood clots.
Monitor blood counts, liver and kidney functions regularly while taking this medication.

Storage Conditions for Valparin Chrono 500

Oral: Store it at controlled room temperature (15-30°C).

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