FDC Limited Generic : Disodium Edetate
281.85 1.55% w/v /40% w/v 11
â€¢ Disodium edetate is a chelating agent used for lowering very high serum calcium (hypercalcemia) levels in emergency situations.
â€¢ Gastrointestinal disorder: Nausea, vomiting, diarrhea
â€¢ Skin: Exfoliative dermatitis, toxic skin and mucous membrane reactions, transient burning and pricking
â€¢ Hematological: Thrombophlebitis, febrile reactions, hyperuricemia, anemia
â€¢ Others: Numbness, headache
Dosage of disodium edetate injection
Adults: Daily dose of 50 mg/kg per body weight up to a maximum dose of 3 kg in 24 hours
Children: Daily dose is 40 mg/kg per body weight up to a maximum dose of 70 mg/kg in 24 hours
â€¢ Disodium edetate is given as an intravenous infusion only after dilution in 500 ml of 5% dextrose injection or 0.5% (0.9% for children) sodium chloride injection.
â€¢ It has to be administered only by a health care professional in a hospital or clinic setting. Final concentration for children should not be more than 3%.
Disodium edetate is contraindicated in patients
â€¢ Allergic to the drug
â€¢ Who have problems in the passage of urine (anuria)
â€¢ For the treatment of generalized atherosclerosis (formation of plaque in blood vessels) that occurs due to old age
NOTE: Disodium edetate is strongly contraindicated to be used instead of the other EDTA agent, calcium disodium EDTA or calcium disodium versenateÂ used to treat serious cases of lead poisoning, or to be used in non FDA approved "chelation therapies" that falsely claim to improve the cardiovascular system. Wrong uses of the drug in both the above cases have lead to fatalities in the past.
â€¢ The rapid intravenous injection could produce a high serum concentration of disodium edetate quickly and cause fatal decreases in serum calcium levels.
â€¢ Toxicity appears to be dependent upon both total dosage and speed of administration.
â€¢ Disodium edetate treatment has the potential to cause electrolyte imbalance; hence cardiac function should be assessed before and during treatment.
The patient should lay in bed for a time after treatment due to the postural hypotension.
Do not use unless the solution is clear and the container is intact.
Use with caution on patients with
â€¢ Heart disease
â€¢ Limited cardiac reserve
â€¢ Congestive heart failure
â€¢ Low potassium levels
â€¢ Pregnant and nursing women
Edetate disodium has the potential to cause
â€¢ Low serum magnesium levels during prolonged therapy
â€¢ Low blood sugar
â€¢ Serum calcium detected by the oxalate method of determination tends to be low in the presence of edetate disodium.
â€¢ Store in a cool, dry place.
â€¢ Keep containers tightly closed.
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