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Diphenoxylate reduces the frequent bowel movement.
It is usually available in combination with atropine to prevent abuse. 

Drug information on Zolfen (50+2.5+0.025) (Diphenoxylate - Combination) from Allied Chemicals & Pharmaceuticals Pvt. Ltd.

Zolfen (50+2.5+0.025)

  Tablet  
Allied Chemicals & Pharmaceuticals Pvt. Ltd.
Generic : Diphenoxylate
 163.00
0.025mg/50mg/2.5mg
10 Tablets
Combination of Generics : Diphenoxylate, Atropine Sulphate,Furazolidone
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Side effects of Diphenoxylate

  Gastrointestinal: Vomiting, nausea, loss of appetite, dry mouth, constipation, paralytic ileus, pancreatitis

  Central nervous system: Headache, confusion, change in mood, dizziness, drowsiness

  Heart: Increase in heart rate

  Skin: Rash and itching, redness, dryness

  Others: Fever, retention of urine, blurring of vision, limb numbness, allergic reaction


• Some of the adverse effects mentioned above are due to the atropine present in the tablet

When is Diphenoxylate not to be taken? (Contraindications)

Diphenoxylate should not be used in patients with:

• Acute diarrhea caused by poison or infection since stopping the diarrhea could result in retention of the poison or the infectious agent in the body
• Obstructive jaundice
• Allergic to the drug
• Children, especially less than 6 years of age since breathing or brain function can get affected

Use with caution in:

• Acute ulcerative colitis, since the medication can cause toxic megacolon
• Liver disease
• Kidney disease


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