View in Hindi Email bookmark
Font : A-A+

Drug information on Nac (Diclofenac) from Systopic Laboratories Pvt. Ltd.


Systopic Laboratories Pvt. Ltd.
Generic : Diclofenac
Update the Drug Info

Drug Name : Diclofenac

Diclofenac(Voltaren) generic Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) prescribed to treat mild-to-moderate musculoskeletal pain. It helps to relieve: • Tenderness, stiffness, and inflammation due to osteoarthritis , rheumatoid arthritis , and ankylosing spondylitis• Musculoskeletal pain due to sprains, strains or other causes. • Migraine headache and other types of headache. • Painful menstrual cramps. • Pre and post-operative pain. • Pain due to kidney stones and gallstones. Diclofenac works by blocking the effects of the cyclo-oxygenase enzyme thereby reducing the synthesis of prostaglandins, which are responsible for causing pain and inflammation.
More Info about Diclofenac

Other Trade Names for Diclofenac

Vijayaganesh Kasinathan
Written & Compiled by Pharmacist Vijayaganesh Kasinathan, B.Pharm, M.Pharm
Dr. Simi Paknikar
Medically Reviewed by Dr. Simi Paknikar, MD
Last Updated on Jan 12, 2018

Medindia currently has information on 3080 generic drugs and 109,870 brands that have their prices listed. New drugs with their prices are listed as and when they get approved by the drug controller. Please do write to us ( if a drug is missing from our comprehensive drug price list.

Medical Condition(s) for which Nac may be prescribed

Overview of Nac

• Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) which is used to treat mild-to-moderate pain, fever, and inflammation.

Side effects of Nac

  Gastrointestinal: Nausea, constipation, flatulence, pain in the abdomen, indigestion, vomiting, bleeding and ulcers in the stomach

  Cardiovascular: Heart failure, fluid accumulation, palpitations, chest pain, high blood pressure

  Central nervous system: Dizziness, headache, hallucination, drowsiness

  Respiratory: Upper respiratory infection, sinusitis, bronchitis, nasopharyngitis, shortness of breath

  Skin: Rashes, itching, increased sweating, exfoliative dermatitis, urticaria, Stevens-Johnson syndrome, toxic epidermal necrolysis

  Genitourinary: Abnormal kidney function, raised concentrations of serum creatinine, urinary tract infection

  Others: Anemia, ringing sensation in the ears, raised level of liver enzymes, liver damage, prolongation in bleeding time, reduced blood counts, allergic reactions

Dosage & When it is to be taken (Indications)

Oral dose:
• The recommended adult dose of diclofenac sodium or potassium is 25 mg to 50 mg three times a day after food.
• The maximum daily dose is 150 mg once daily after food.
• The dose of diclofenac sodium extended-release tablets is 100 mg once daily.
• The maximum daily dose in treating rheumatoid arthritis is 225 mg after food.

Parenteral dose:
• The prescribed adult dose is 37.5 mg to be administered intravenously for every 6 to 8 hours.
• The maximum daily dose is 150 mg once daily.

Eye drops:
• Instill 1 drop into the affected eye 4 times a day or as directed by the ophthalmologist. Do not use soft contact lenses while using diclofenac drops.

Topical application:
• Apply diclofenac gel or cream or spray twice daily to the affected part or as directed by the physician. Do not apply on broken skin. A diclofenac patch is also available, which should be removed while bathing.

Adults Dose:
• Diclofenac suppositories should be inserted into the rectum one to three times daily with the maximum daily dose of 150mg.
Child Dose:
• The dose of diclofenac suppositories vary with the age but usually between 1 and 3 mg/kg body weight daily in two or three divided doses.

How to use Nac?

• Diclofenac tablets for oral use should be taken by mouth along with food to avoid gastric discomfort.
• Granules of diclofenac are taken by mixing the granules with sufficient quantity of water and swallowed immediately.
• Do not chew, crush or break the contents of enteric-coated or film-coated tablets.

When is Nac not to be taken? (Contraindications)

Diclofenac is not recommended in patients with the following conditions-

• Allergy to diclofenac or any other related NSAID
• Asthma or breathing problems
• History of peptic ulcer or stomach bleeding
• Severe kidney or liver disease
• Reported allergic reaction after taking aspirin
• Treating pain in coronary artery bypass graft (CABG)
• Fluid retention or edema

The use of diclofenac in pregnancy should be avoided particularly in the third trimester to avoid premature closure of ductus arteriosus. Diclofenac is also not recommended during breastfeeding or during labor.

Warnings and Precautions for Nac

• While administering the intravenous injection, it is necessary to hydrate the patient in order to reduce the risk of adverse effects on the kidney.
• Caution is required in patients with mild liver or kidney impairment but diclofenac should not be used in moderate-or-severe damage.
• It is usually advised to start with the lowest effective dose and a treatment for a short duration if possible.
• Patients should be monitored for the signs and symptoms of stomach bleeding during diclofenac therapy because of the risk of developing a peptic ulcer.
• Monitor for the blood counts, kidney and liver function and blood pressure regularly in patients on long-term treatment with diclofenac.
• Diclofenac may increase the risk of heart attack or stroke.
• The use of another NSAID along with diclofenac is not recommended but diclofenac can be used in combination with opioids in case of severe pain or swelling.
• Alcohol intake with diclofenac is not encouraged because of the increased risk of stomach bleeding or ulcer.
• Treatment with diclofenac should be discontinued immediately and when serious skin reactions occur.
• A high injectable dose should be avoided in patients with cardiovascular disease or uncontrolled hypertension. Injectable diclofenac should also not be administered to patients with dehydration, bleeding problems or at a high risk of bleeding.

Other Precautions for Nac

• Patients should be advised not to interchange the formulations of diclofenac for their treatment as the formulations may not be bioequivalent.
• It is recommended to report to the emergency center any signs and symptoms of allergic reactions, gastrointestinal complaints, cardiovascular events, liver toxicity, unusual weight gain or weight loss.

Drug Interactions of Nac

• Concomitant administration of diclofenac and aspirin or other NSAIDs is not advised because of the risk of increased adverse effects.
• Drugs such as methotrexate and cyclosporine should not be taken with diclofenac to avoid the potential for kidney toxicity.

• Diclofenac may decrease the antihypertensive effects of blood pressure lowering medications including ACE inhibitors such as lisinopril, enalapril, perindopril, and ramipril when taken together.
• Diclofenac may reduce the natriuretic (sodium-losing) effects of frusemide and thiazide diuretics and patients must be monitored for signs and symptoms of renal failure.
• Warfarin when taken with diclofenac results in a serious risk of gastrointestinal bleeding.
• Lithium when taken concomitantly with diclofenac results in the elevation of plasma lithium levels and reduced renal lithium clearance.

• Enzyme inducers like rifampicin may reduce the blood levels of diclofenac, while enzyme inhibitors like voriconazole may increase its level.

Storage Conditions for Nac

• Store at a controlled room temperature between 20°C and 25°C.
• Keep away from excess light and moisture.
• Keep out of the reach of children.

Disclaimer : updates the prices regularly, however despite that there may be discrepancies in the prices displayed. This can be due to many reasons including -
  • Difference in GST/local taxes
  • Change in price by the company
  • Updation of information may not have happened at the right time
For the above reasons Medindia cannot be held liable for any action taken based on the information provided by its website. The purpose of this website is to only provide the initial guidance and it does not intend to replace professional medical opinion in any manner whatsoever.

Add Drugs
Buy Medicines (Drug) at Concessional Price from India
Substitutes for Nac

View all

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)