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Drug information on Duplat (50 mg) (Cisplatin) from Samarth Pharma Pvt. Ltd.

Duplat (50 mg)   Injection Samarth Pharma Pvt. Ltd. Generic : Cisplatin	310.00 50ml 1

Information Checked by Dhanalakshmi Chinnuswamy, Diploma in Pharmacy, MBA (Healthcare)

Further Checked by The Medindia Medical Review Team on February, 2, 2017

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Bladder Cancer

Bone Marrow Transplantation

Cancer- Oropharyngeal Cancer of the Head and Neck

Cervical Cancer

Gallbladder Cancer

Gastric Cancer

Laryngeal Cancer

Lung Cancer

•   Toxic effects : Nephrotoxicity (kidney damage) and ototoxicity (ear damage).

•   Severe effects : Stroke, heart attack, electrolyte disturbances and allergic reactions.

•   Gastrointestinal : Loss of appetite, nausea and vomiting.

•   ENT : Ringing in the ear, loss of hearing and deafness.

Adult: IV- Metastatic ovarian cancer As monotherapy: 100 mg/m² per cycle, given as a single dose once every 4 week.
For combination therapy with cyclophosphamide: 75-100 mg/m² on day 1 of every 4-week cycle. Metastatic testicular tumors 20 mg/m²/day for 5 days per cycle. Advanced bladder cancer 50-70 mg/m² per cycle once every 3-4 week.

It comes as a solution for injection to be administered by a healthcare provider into the vein.

Contraindicated in patients with hearing impairment, kidney impairment and hypersensitivity.

• Caution should be exercised in patients with history of bone marrow suppression, kidney or liver disease, any allergy, who are taking other medications, elderly, children, during pregnancy and breast-feeding.

• Monitor complete blood counts, ear and neurological functions regularly while taking this medication.

• Patients may develop with increased risk of nephrotoxicity (kidney damage with irritation), drink adequate fluids to prevent damage.

• Avoid vaccination while taking this medication.

• It may develop new type of cancer; if you have any doubt consult with your doctor regarding this.

Avoid excess dosage.

This drug is used only under the supervision of physician.