Glaxo SmithKline Pharmaceuticals Ltd. Generic : Cephaloridine
30.57 500mg 1
• Cephaloridine is a semisynthetic antibiotic with antibacterial activity, derived from the natural antibiotic, cephalosporin C.
• Cefaloridine has marked dose-related nephrotoxicity.
• The drug accumulates in the proximal renal tubular cell, probably by active anionic transport.
• Probenecid, which blocks such transport, is given to patients to eliminate the nephrotoxicity of cephaloridine when it occurs.
• Other side effects common to first-generation cephalosporin class of antibiotics are
Diarrhea, nausea, rash, pain and inflammation at the injection site
• Gastrointestinal: Pseudomembranous colitis (inflammation of the colon)
• Hematological disorders: Esinophilia, low levels of prothrombin, abnormalities of blood coagulation
• Nephrological disorder: Renal damage at large doses
• Others: Vomiting, headache, dizziness, fungal infections of the mouth and vagina, fever
• Certain complications that maybe caused by the use of cephaloridine include seizures, coma, chronic renal failure, acute renal failure and death.
• The recommended dose for cephaloridine is a daily dose of 1 to 3 g.
• Doses more than 4 g can prove to be nephrotoxic to the patients.
• Cephaloridine should be taken via intrathecal for the duration of 24 hours and via intramuscular for the duration of 12 hours.
• A daily dose of more than 4 g of cephaloridine may be toxic to the kidneys of normal patients.
• Smaller doses may damage the kidneys of patients with underlying renal disease or those receiving other nephrotoxic drugs.
• Hence patients with any known renal impairment should be monitored closely.
• Cephaloridine should not be used in patients with high levels of urea and creatinine.
• The entire course of this antibiotic should be completed even if the patients feel better; this will make sure the infection is cured.
• There have been instances of renal tubular necrosis with uremia and death after large doses in some patients with progressive renal disease, and toxic effects on the central nervous system after intrathecal administration.
• Cephaloridine interacts with amikacin (sulfate), ethacrynic acid, frusemide or furosemide, penicillamine, reviparin sodium and anticoagulants like acenocoumarol, dicoumarol, phenindione and phenprocoumon.
• The drug should be stored at 2-8°C temperature away from moisture and direct sunlight.
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